Beura L K, Rosato P C, Masopust D
Department of Microbiology and Immunology, University of Minnesota, Minneapolis, MN.
Center for Immunology, University of Minnesota, Minneapolis, MN.
Am J Transplant. 2017 May;17(5):1167-1175. doi: 10.1111/ajt.14101. Epub 2016 Dec 9.
Recent studies have established resident memory T cells (T ) as the dominant memory lymphocyte population surveying most nonlymphoid tissues. Unlike other memory T cell lineages, T do not recirculate through blood and are permanently confined to their tissue of residence. T orchestrate local immune responses and have been shown to accelerate local pathogen control in many experimental infection models. Here we briefly summarize recent advances in T differentiation, maintenance, and their protective function. While little is known, we have speculated on the potential implications of T for transplantation biology. Areas of emphasis include the role of passenger T in controlling latent viral recrudescence in donor organs, donor T as a source of graft-versus-host disease, the ability of T to potently induce inflammation through sensing and alarm functions, and differentiation of host T cells into T in response to local cues inside the allograft. Further investigation of T in the context of transplantation might identify therapeutic targets to prolong graft survival.
最近的研究已证实组织驻留记忆T细胞（T细胞）是监测大多数非淋巴组织的主要记忆淋巴细胞群体。与其他记忆T细胞谱系不同，T细胞不会通过血液再循环，而是永久局限于其驻留组织。T细胞协调局部免疫反应，并且在许多实验性感染模型中已显示出可加速局部病原体的控制。在此，我们简要总结T细胞分化、维持及其保护功能方面的最新进展。尽管我们了解甚少，但我们推测了T细胞对移植生物学的潜在影响。重点领域包括过客T细胞在控制供体器官中潜伏病毒复发方面的作用、供体T细胞作为移植物抗宿主病的来源、T细胞通过传感和警报功能有效诱导炎症的能力，以及宿主T细胞响应同种异体移植物内的局部信号分化为T细胞的过程。在移植背景下对T细胞的进一步研究可能会确定延长移植物存活时间的治疗靶点。
