Chen Yu-fan, Liu Shi-yin, Liang Zhi-bin, Lv Ming-fa, Zhou Jia-nuan, Zhang Lian-hui
1. Integrative Microbiology Research Centre, South China Agricultural University, Guangzhou 510642, China; 2. Guangdong Province Key Laboratory of Microbial Signals and Disease Control, Guangzhou 510642, China.
Yi Chuan. 2016 Oct 20;38(10):881-893. doi: 10.16288/j.yczz.16-141.
Microbial drug resistance has become a serious problem of global concern, and the evolution and regulatory mechanisms of microbial drug resistance has become a hotspot of research in recent years. Recent studies showed that certain microbial resistance mechanisms are regulated by quorum sensing system. Quorum sensing is a ubiquitous cell-cell communication system in the microbial world, which associates with cell density. High-density microbial cells produce sufficient amount of small signal molecules, activating a range of downstream cellular processes including virulence and drug resistance mechanisms, which increases bacterial drug tolerance and causes infections on host organisms. In this review, the general mechanisms of microbial drug resistance and quorum-sensing systems are summarized with a focus on the association of quorum sensing and chemical signaling systems with microbial drug resistance mechanisms, including biofilm formation and drug efflux pump. The potential use of quorum quenching as a new strategy to control microbial resistance is also discussed.
微生物耐药性已成为一个全球关注的严重问题，近年来微生物耐药性的进化和调控机制已成为研究热点。最近的研究表明，某些微生物耐药机制受群体感应系统调控。群体感应是微生物界普遍存在的一种细胞间通讯系统，与细胞密度相关。高密度的微生物细胞产生足够量的小信号分子，激活一系列下游细胞过程，包括毒力和耐药机制，这增加了细菌的耐药性并导致宿主生物体感染。在本综述中，总结了微生物耐药性和群体感应系统的一般机制，重点关注群体感应和化学信号系统与微生物耐药机制的关联，包括生物膜形成和药物外排泵。还讨论了群体淬灭作为控制微生物耐药性新策略的潜在用途。
