Tu Ye, Wang Xinxia, Lu Ying, Zhang He, Yu Yuan, Chen Yan, Liu Junjie, Sun Zhiguo, Cui Lili, Gao Jing, Zhong Yanqiang
Department of Medical Affairs, East Hospital, Tongji University School of Medicine; Department of Pharmaceutical Science, School of Pharmacy, Second Military Medical University.
Department of Pharmacy, East Hospital of Hepatobiliary Surgery.
Int J Nanomedicine. 2016 Oct 25;11:5549-5561. doi: 10.2147/IJN.S109552. eCollection 2016.
We recently reported that electret, which was prepared by a corona charging system with polypropylene film, could enhance the transdermal delivery of several drugs of low molecular weight. The aim of this study was to investigate whether electret could enhance the transdermal delivery of protein drugs by -trimethyl chitosan nanoparticles (TMC NPs) prepared by an ionic gelation method. A series of experiments were performed, including in vitro skin permeation assays and anti-inflammatory effects, to evaluate the transdermal delivery of protein drugs by TMC NPs in the presence of electret. The results showed that in the presence of electret, the transdermal delivery of protein drugs in TMC NPs was significantly enhanced, as demonstrated by in vitro permeation studies and confocal laser scanning microscopy. Notably, superoxide dismutase-loaded TMC NPs combined with electret exhibited the best inhibitory effect on the edema of the mouse ear. TMC NPs combined with electret represent a novel platform for the transdermal delivery of protein drugs.
我们最近报道，通过带有聚丙烯薄膜的电晕充电系统制备的驻极体，可以增强几种低分子量药物的透皮递送。本研究的目的是调查驻极体是否能增强通过离子凝胶法制备的 - 三甲基壳聚糖纳米颗粒（TMC NPs）对蛋白质药物的透皮递送。进行了一系列实验，包括体外皮肤渗透试验和抗炎作用，以评估在驻极体存在下TMC NPs对蛋白质药物的透皮递送。结果表明，在驻极体存在下，TMC NPs中蛋白质药物的透皮递送显著增强，体外渗透研究和共聚焦激光扫描显微镜证明了这一点。值得注意的是，负载超氧化物歧化酶的TMC NPs与驻极体结合对小鼠耳部水肿表现出最佳抑制作用。TMC NPs与驻极体结合代表了一种蛋白质药物透皮递送的新型平台。
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