Shafiei Reza, Teshnizi Saeed Hosseini, Kalantar Kurosh, Gholami Maryam, Mirzaee Golnush, Mirzaee Fatemeh
Vector-Borne Diseases Research Center, North Khorasan University of Medical Sciences, Bojnurd, Iran.
Clinical Research Development Center of Children Hospital, Hormozgan University of Medical Sciences, Bandar Abbas, Iran.
J Parasitol Res. 2016;2016:1425147. doi: 10.1155/2016/1425147. Epub 2016 Oct 17.
Human cystic echinococcosis (HCE), a zoonotic infection of the larval stage of , has high effect on public health in human population all around the world. Iran is one of the most important endemic areas in the Middle East. This systematic review and meta-analysis was performed to evaluate the seroprevalence of HCE in Iranian population. An electronic search for articles from 1985 until April 2015 was performed using data bases PubMed, Scopus, Google Scholar, Magiran, IranMedex, Iran Doc, and Scientific Information Database (SID) both in English and in Persian. A random-effects meta-analysis was used to combine results from individual studies. The information was analyzed by STATA version 11.1. A total of 33 articles met our eligibility criteria and were included in a meta-analysis. The pooled estimate of the prevalence of HCE based on random-effects model was estimated 6.0% (95% CI: 4.0%, 7.0%). The prevalence of the disease significantly increased with age and prevalence rate in males was significantly lower than females ( < 0.001). The using of CIE or CCIEP method was also significantly greater than the other methods ( < 0.001). There was a publication bias in prevalence of studies. HCE is highly prevalent in Iran. Public education for preventive strategies and finally reducing transmission of the parasite and infection in population is needed.
人体囊型包虫病（HCE）是由幼虫阶段引起的一种人畜共患感染病，对全球人类的公共卫生有很大影响。伊朗是中东地区最重要的流行地区之一。本系统评价和荟萃分析旨在评估伊朗人群中HCE的血清流行率。利用PubMed、Scopus、谷歌学术、Magiran、IranMedex、Iran Doc和科学信息数据库（SID）等数据库，以英文和波斯文对1985年至2015年4月的文章进行了电子检索。采用随机效应荟萃分析来合并各个研究的结果。信息通过STATA 11.1版本进行分析。共有33篇文章符合我们的纳入标准并被纳入荟萃分析。基于随机效应模型的HCE患病率合并估计值为6.0%（95%可信区间：4.0%，7.0%）。该疾病的患病率随年龄显著增加，男性患病率显著低于女性（P<0.001）。使用CIE或CCIEP方法的患病率也显著高于其他方法（P<0.001）。研究患病率存在发表偏倚。HCE在伊朗高度流行。需要开展关于预防策略的公众教育，最终减少寄生虫传播和人群感染。
