术前阿苯达唑对肝包虫囊肿原头蚴活力的影响
Efficacy of Preoperative Albendazole on Protoscoleces Viability in Hydatid Cyst of the Liver.
作者信息
Vahidirad Ali, Mansouri Mostafa, Shamshirian Ali, Berenji Fariba, Motie Mohammad Reza
机构信息
Department of Surgery, Golestan University of Medical Sciences, Gorgan, Iran.
Student Research Committee, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
出版信息
Iran J Parasitol. 2022 Oct-Dec;17(4):483-487. doi: 10.18502/ijpa.v17i4.11274.
BACKGROUND
Optimal duration for medical therapy of liver hydatid cysts before surgery in not certainly defined yet. In this study, we aimed to evaluate the effectiveness of 2 weeks preoperative albendazole in decreasing viable cysts.
METHODS
Patients referring to Imam Reza Hospital, Mashhad, Iran with a diagnosis of hepatic hydatid cyst were randomly divided into intervention (44 patients) and control (46 patients) groups. The case group were treated with oral albendazole before surgery and the control group underwent surgery without albendazole therapy. Efficacy of albendazole on the reduction of prevalence and viability of the protoscoleces was finally evaluated.
RESULTS
A number of 90 patients were included in the final analysis. Protoscoleces were reported alive in 10 (22.7%) and 17 (36.9%) of patients in the case and control group, respectively. The decrease of live protoscoleces in case group was not statistically significant (=0.14).
CONCLUSION
Decrease in the viability of protoscoleces in hepatic hydatid cysts after 2 weeks administration of oral albendazole at a dose of 10 mg/kg/day preoperatively, is not significant. Optimal duration of medical treatment before surgery seems to be 4 weeks or more.
背景
肝包虫囊肿手术前药物治疗的最佳时长尚未明确界定。在本研究中，我们旨在评估术前两周使用阿苯达唑减少存活囊肿的有效性。
方法
转诊至伊朗马什哈德伊玛目礼萨医院、被诊断为肝包虫囊肿的患者被随机分为干预组（44例患者）和对照组（46例患者）。病例组在手术前接受口服阿苯达唑治疗，对照组未接受阿苯达唑治疗直接进行手术。最终评估阿苯达唑对原头节患病率和活力降低的疗效。
结果
90例患者纳入最终分析。病例组和对照组分别有10例（22.7%）和17例（36.9%）患者的原头节被报告存活。病例组存活原头节的减少无统计学意义（P = 0.14）。
结论
术前每天按10mg/kg的剂量口服阿苯达唑两周后，肝包虫囊肿中原头节活力的降低并不显著。手术前药物治疗的最佳时长似乎为4周或更长。
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