生命之初的人类微生物组。

The Human Microbiome before Birth.

机构信息

Department of Medicine, NYU Langone Medical Center, New York, NY 10016, USA; Department of Microbiology, NYU Langone Medical Center, New York, NY 10016, USA.

Department of Medicine, NYU Langone Medical Center, New York, NY 10016, USA.

出版信息

Cell Host Microbe. 2016 Nov 9;20(5):558-560. doi: 10.1016/j.chom.2016.10.014.

DOI:10.1016/j.chom.2016.10.014

PMID:27832586

Abstract

The conservation of the microbiota within humans and other hominids suggests an ancient assembly that has been selected to optimize host fitness. Pregnancy induces changes in the maternal microbiome just before the intergenerational hand-off of the microbiota. Interventions, including peri-partum antibiotics and Cesarean sections, may have unintended effects on babies.

摘要

人类和其他原始人类体内微生物组的保护表明，远古时期就已经存在这种组合，且经过了选择，以优化宿主的健康。在母婴两代微生物交接之前，妊娠会引起母体微生物组的变化。包括围产期使用抗生素和剖宫产在内的干预措施可能会对婴儿产生意想不到的影响。