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变种提取物改善小鼠胶原诱导性关节炎。

The Extract of var. Ameliorates Collagen-Induced Arthritis in Mice.

作者信息

Kim A-Ram, Kim Hyuk Soon, Kim Do Kyun, Lee Jun Ho, Yoo Young Hyo, Kim Jeom Yong, Park Sun Kyu, Nam Seung Taek, Kim Hyun Woo, Park Young Hwan, Lee Dajeong, Lee Min Beom, Kim Young Mi, Choi Wahn Soo

机构信息

Department of Immunology, College of Medicine, Konkuk University, Chungju 27478, Republic of Korea.

Green Cross Wellbeing Co., Ltd., Seongnam 13595, Republic of Korea.

出版信息

Evid Based Complement Alternat Med. 2016;2016:3915013. doi: 10.1155/2016/3915013. Epub 2016 Oct 20.

DOI:10.1155/2016/3915013
PMID:27840652
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5093284/
Abstract

var. (CZ) has been used for beverage or tea and also as folk medicine for the remedy of diverse inflammatory diseases. Nevertheless, the therapeutic effect of CZ on arthritis remains to be unknown. In this paper we aim to investigate the CZ's antiarthritic effect and mechanism of action both in vitro and in vivo. To assess CZ's antiarthritic effect, mouse models of type II collagen-induced arthritis (CIA) were used. Mice were used to gauge clinical arthritis index and histopathological changes. Reverse transcriptase-polymerase chain reaction (RT-PCR), western blotting, electrophoretic mobility shift assay (EMSA), and other biological methods were adopted to measure CZ's effect on arthritis and to understand the veiled mechanism of action. CZ greatly suppressed CIA, histopathological score, bone erosion, and osteoclast differentiation. Mechanistically, CZ inhibited the production of various inflammatory and arthritic mediators like inflammatory cytokines, matrix metalloproteinases (MMPs), and chemokines. Of note, CZ significantly suppressed the activation of the NF-B pathway in vivo. CZ exerted an antiarthritic effect in CIA mice by curbing the production of crucial inflammatory and arthritis mediators. This study warrants further investigation of CZ for the use in human rheumatoid arthritis (RA).

摘要

变种（CZ）已被用于制作饮料或茶，也作为民间药物用于治疗各种炎症性疾病。然而，CZ对关节炎的治疗效果仍不清楚。在本文中，我们旨在研究CZ在体外和体内的抗关节炎作用及其作用机制。为了评估CZ的抗关节炎作用，使用了II型胶原诱导的关节炎（CIA）小鼠模型。通过小鼠来评估临床关节炎指数和组织病理学变化。采用逆转录聚合酶链反应（RT-PCR）、蛋白质印迹法、电泳迁移率变动分析（EMSA）及其他生物学方法来测定CZ对关节炎的作用，并了解其潜在的作用机制。CZ显著抑制了CIA、组织病理学评分、骨侵蚀和破骨细胞分化。从机制上讲，CZ抑制了多种炎症和关节炎介质的产生，如炎性细胞因子、基质金属蛋白酶（MMPs）和趋化因子。值得注意的是，CZ在体内显著抑制了NF-κB通路的激活。CZ通过抑制关键炎症和关节炎介质的产生，在CIA小鼠中发挥了抗关节炎作用。本研究值得进一步探讨CZ在人类类风湿性关节炎（RA）中的应用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e742/5093284/283de2423ed2/ECAM2016-3915013.008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e742/5093284/6316b07cf11f/ECAM2016-3915013.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e742/5093284/c6683b2cfb89/ECAM2016-3915013.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e742/5093284/fdcb5db01c5c/ECAM2016-3915013.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e742/5093284/bff53b3663c7/ECAM2016-3915013.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e742/5093284/596b6a7a56f6/ECAM2016-3915013.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e742/5093284/5ffa25dd80b2/ECAM2016-3915013.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e742/5093284/e1e0fedb726e/ECAM2016-3915013.007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e742/5093284/283de2423ed2/ECAM2016-3915013.008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e742/5093284/6316b07cf11f/ECAM2016-3915013.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e742/5093284/c6683b2cfb89/ECAM2016-3915013.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e742/5093284/fdcb5db01c5c/ECAM2016-3915013.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e742/5093284/bff53b3663c7/ECAM2016-3915013.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e742/5093284/596b6a7a56f6/ECAM2016-3915013.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e742/5093284/5ffa25dd80b2/ECAM2016-3915013.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e742/5093284/e1e0fedb726e/ECAM2016-3915013.007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e742/5093284/283de2423ed2/ECAM2016-3915013.008.jpg

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