肺癌流行病学与基因组学中的种族和民族差异。
Racial and Ethnic Differences in the Epidemiology and Genomics of Lung Cancer.
作者信息
Schabath Matthew B, Cress Douglas, Munoz-Antonia Teresita
机构信息
Department of Cancer Epidemiology, Moffitt Cancer Center, Tampa, FL, USA.
出版信息
Cancer Control. 2016 Oct;23(4):338-346. doi: 10.1177/107327481602300405.
BACKGROUND
Lung cancer is the most common cancer in the world. In addition to the geographical and sex-specific differences in the incidence, mortality, and survival rates of lung cancer, growing evidence suggests that racial and ethnic differences exist.
METHODS
We reviewed published data related to racial and ethnic differences in lung cancer.
RESULTS
Current knowledge and substantive findings related to racial and ethnic differences in lung cancer were summarized, focusing on incidence, mortality, survival, cigarette smoking, prevention and early detection, and genomics. Systems-level and health care professional-related issues likely to contribute to specific racial and ethnic health disparities were also reviewed to provide possible suggestions for future strategies to reduce the disproportionate burden of lung cancer.
CONCLUSIONS
Although lung carcinogenesis is a multifactorial process driven by exogenous exposures, genetic variations, and an accumulation of somatic genetic events, it appears to have racial and ethnic differences that in turn impact the observed epidemiological differences in rates of incidence, mortality, and survival.
背景
肺癌是全球最常见的癌症。除了肺癌发病率、死亡率和生存率存在地理及性别差异外，越来越多的证据表明存在种族和民族差异。
方法
我们回顾了已发表的有关肺癌种族和民族差异的数据。
结果
总结了与肺癌种族和民族差异相关的现有知识和实质性发现，重点关注发病率、死亡率、生存率、吸烟、预防和早期检测以及基因组学。还审查了可能导致特定种族和民族健康差距的系统层面和医疗保健专业人员相关问题，为未来减轻肺癌不成比例负担的策略提供可能的建议。
结论
尽管肺癌发生是一个由外源性暴露、基因变异和体细胞基因事件积累驱动的多因素过程，但似乎存在种族和民族差异，进而影响观察到的发病率、死亡率和生存率的流行病学差异。
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