Yadin O, Sarov B, Naggan L, Slor H, Shoenfeld Y
Department of Medicine D, Soroka Medical Center, Faculty of Health Sciences, Beer-Sheva, Israel.
Clin Exp Immunol. 1989 Mar;75(3):402-6.
Autoantibodies are often found among healthy individuals. The significance of these findings, regarding the potential development of overt autoimmune disease and the severity of such an eventuality, is as yet unclear. In order to elucidate these issues 506 healthy women were screened and 60 women of child-bearing age were found to posses high titres of various anti-nuclear antibodies. After a 5-year follow-up, 57 of these 60 women were found to have autoantibodies to a variety of autoantigens. Seven of the women had some symptoms that could be associated with the presence of the antibodies (i.e. arthritis, multiple abortions, Raynaud's phenomenon), however, none exhibited overt clinical signs of an autoimmune disease. Our study may point to the fact that in normal subjects (women aged 22-44 years) high titres of natural autoantibodies are not necessarily indicative of a high risk of developing an overt autoimmune condition, at least for a follow-up period of 5 years.
健康个体中常常能发现自身抗体。这些发现对于显性自身免疫性疾病潜在发展的意义以及这种可能性的严重程度，目前尚不清楚。为了阐明这些问题，对506名健康女性进行了筛查，发现60名育龄女性拥有高滴度的各种抗核抗体。经过5年的随访，这60名女性中有57名被发现对多种自身抗原具有自身抗体。其中7名女性有一些可能与抗体存在相关的症状（如关节炎、多次流产、雷诺现象），然而，没有一人表现出自身免疫性疾病的明显临床体征。我们的研究可能表明，在正常受试者（22至44岁的女性）中，高滴度的天然自身抗体不一定表明发生显性自身免疫性疾病的风险很高，至少在5年的随访期内是这样。
