Çınar Mehmet, Eryılmaz Özlem Gün, Özel Şule, Fındık Rahime Bedir, Kansu Hatice, Özakşit Gülnur
Department of Obstetrics and Gynecology, Zekai Tahir Burak Women's Health Education and Research Hospital, Ankara, Turkey.
J Exp Ther Oncol. 2016 Nov;11(4):269-273.
To evaluate the association of the oxidative stress markers in patients with endometrial polyp.
A total of forty nine patients between 28-47 years of ages who have a suspect evidence of endometrial polyp on transvaginal sonography were enrolled for the study. Hysterosonography was applied all of the patients and patients then were divided into two groups in terms of their hysteroscopic findings. Group 1(control group, n=27) defined who has no endometrial pathology and group 2 (study group, n=22) defined has one or more endometrial polyp on hysteroscopy with guided biopsy. The diagnosis was established by histopathological examination polyps. The parameters compared between groups were; age, body mass index, catalase (CAT), xsantine oxidase (XO), malondialdehyde (MDA) levels.
There were no statistically significant differences between groups in terms of age and BMI. Catalase, xsantine oxidase and malondialdehyde levels were statically significantly different between the groups (p < 0,05). The mean of polyp diameter size were 17.95 ±0.45 mm and the number of the polyp per patient was 1.54 ± 0.67.
According to our study, serum catalase, xsantine oxidase and malondialdehyde levels may be discriminative parameters for patients with endometrial polyp.
评估子宫内膜息肉患者氧化应激标志物之间的关联。
本研究纳入了49例年龄在28 - 47岁之间、经阴道超声检查怀疑有子宫内膜息肉的患者。对所有患者进行子宫超声造影检查，然后根据宫腔镜检查结果将患者分为两组。第1组（对照组，n = 27）为无子宫内膜病变者，第2组（研究组，n = 22）为宫腔镜引导活检发现有一个或多个子宫内膜息肉者。息肉的诊断通过组织病理学检查确定。比较两组之间的参数有：年龄、体重指数、过氧化氢酶（CAT）、黄嘌呤氧化酶（XO）、丙二醛（MDA）水平。
两组在年龄和体重指数方面无统计学显著差异。两组之间过氧化氢酶、黄嘌呤氧化酶和丙二醛水平有统计学显著差异（p < 0.05）。息肉平均直径大小为17.95 ± 0.45 mm，每位患者息肉数量为1.54 ± 0.67。
根据我们的研究，血清过氧化氢酶、黄嘌呤氧化酶和丙二醛水平可能是子宫内膜息肉患者的鉴别参数。
