Watanabe Masataka
Department of Physiological Psychology, Tokyo Metropolitan Institute of Medical Science.
Brain Nerve. 2016 Nov;68(11):1291-1299. doi: 10.11477/mf.1416200593.
Patients with the damage to the orbital region of the prefrontal cortex and monkeys with lesions in this area show impairment in emotional and motivational behavior. They also have difficulty in the extinction of learned behavior and in the reversal learning. This brain area is concerned with not only the value estimation of reward and aversive stimuli but also the expectation of these stimuli. The lateral prefrontal cortex plays an important role in the integration of emotion/motivation and cognition. The medial prefrontal cortex is concerned with action selection based on the previous reward history. The ventrolateral prefrontal cortex that comprises the anterior parts of the orbital and inferior medial prefrontal cortex plays an important role in emotion-based decision-making.
前额叶皮质眶区受损的患者以及该区域有损伤的猴子，在情绪和动机行为方面表现出障碍。它们在习得行为的消退和逆向学习方面也存在困难。这个脑区不仅与奖励和厌恶刺激的价值评估有关，还与对这些刺激的预期有关。外侧前额叶皮质在情绪/动机与认知的整合中起重要作用。内侧前额叶皮质与基于先前奖励历史的行动选择有关。包括眶额和内侧前额叶皮质前部的腹外侧前额叶皮质在基于情绪的决策中起重要作用。
