Mahboubi Mohaddese, Feizabadi Mohammad Mehdi, Khamechian Tahereh, Kazempour Nastaran, Razavi Zadeh Mohsen, Sasani Farhang, Bekhradi Mohsen
Microbiology Department, Medicinal Plant Research Center of Barij, Kashan, Iran.
Department of Microbiology, School of Medicine, Tehran University of Medical Science, Tehran, Iran.
World J Plast Surg. 2016 Sep;5(3):259-264.
is one of the most causative organisms in the skin wound infections. Development of resistant to current treatments in individuals with low immunity is a global concern. The aim of this study was to evaluate the efficacy of herbal formulation against skin wound infection
The efficacy of herbal formulation containing and essential oils was evaluated in comparison to mupirocin against Methicillin Resistant (MRSA) related skin wound infection in mice animal model.
The herbal cream and mupirocin decreased the log CFU by 2.5±0.26 and 2.46±0.32, respectively, while the log CFU of from wound skin were 5.9±0.26 and 5.65±0.23 for placebo and control groups, respectively. Moreover, the histological examinations showed that this cream improved the wound healing and increased the collagen deposition and wound contraction.
This natural new formulation with and essential oils could be recommended as a new candidate for wound healing.
是皮肤伤口感染中最主要的致病微生物之一。免疫力低下个体对当前治疗产生耐药性的发展是一个全球关注的问题。本研究的目的是评估一种草药制剂对皮肤伤口感染的疗效。
在小鼠动物模型中，将含有和精油的草药制剂与莫匹罗星对比，评估其对耐甲氧西林相关皮肤伤口感染的疗效。
草药乳膏和莫匹罗星分别使对数菌落形成单位减少了2.5±0.26和2.46±0.32，而安慰剂组和对照组伤口皮肤的对数菌落形成单位分别为5.9±0.26和5.65±0.23。此外，组织学检查表明，这种乳膏促进了伤口愈合，增加了胶原蛋白沉积和伤口收缩。
这种含有和精油的天然新制剂可被推荐为伤口愈合的新候选药物。
