Department of Oral Pathology, School of Dentistry, Chonnam National University, Gwangju 61186, Korea.
Department of Oral and Maxillofacial Surgery, School of Stomatology, Dalian Medical University, Dalian 116044, China.
Molecules. 2019 Aug 23;24(17):3064. doi: 10.3390/molecules24173064.
Epidermal inflammation is caused by various bacterial infectious diseases that impair the skin health. Feruloylserotonin (FS) belongs to the hydroxycinnamic acid amides of serotonin, which mainly exists in safflower seeds and has been proven to have anti-inflammatory and antioxidant activities. Human epidermis mainly comprises keratinocytes whose inflammation causes skin problems. This study investigated the protective effects of FS on the keratinocyte with lipopolysaccharides (LPS)-induced human HaCaT cells and elucidated its underlying mechanisms of action. The mechanism was investigated by analyzing cell viability, PGE levels, cell apoptosis, nuclear factor erythroid 2-related factor 2 (Nrf2) translocation, and TLR4/NF-κB pathway. The anti-inflammatory effects of FS were assessed by inhibiting the inflammation via down-regulating the TLR4/NF-κB pathway. Additionally, FS promoted Nrf2 translocation to the nucleus, indicating that FS showed anti-oxidative activities. Furthermore, the antioxidative and anti-inflammatory effects of FS were found to benefit each other, but were independent. Thus, FS can be used as a component to manage epidermal inflammation due to its anti-inflammatory and anti-oxidative properties.
表皮炎症是由各种细菌性传染病引起的，这些传染病会损害皮肤健康。阿魏酰血清素（FS）属于血清素的羟基肉桂酰胺，主要存在于红花种子中，已被证明具有抗炎和抗氧化活性。人类表皮主要由角朊细胞组成，其炎症会导致皮肤问题。本研究探讨了 FS 对脂多糖（LPS）诱导的人 HaCaT 细胞中角朊细胞的保护作用，并阐明了其作用机制。通过分析细胞活力、PGE 水平、细胞凋亡、核因子红细胞 2 相关因子 2（Nrf2）易位以及 TLR4/NF-κB 途径来研究该机制。FS 通过抑制 TLR4/NF-κB 途径来抑制炎症，从而发挥抗炎作用。此外，FS 促进 Nrf2 向核内易位，表明 FS 具有抗氧化活性。此外，还发现 FS 的抗氧化和抗炎作用相互受益，但彼此独立。因此，由于 FS 具有抗炎和抗氧化特性，可将其作为一种成分用于管理表皮炎症。
