Mahboubi Mohaddese, Taghizadeh Mohsen, Khamechian Tahereh, Tamtaji Omid Reza, Mokhtari Rasoul, Talaei Sayyed Alireza
Microbiology Department, Medicinal Plant Research Center of Barij, Kashan, Iran.
Research Center for Biochemistry and Nutrition in Metabolic diseases, Kashan University of Medical Sciences, Kashan, Iran.
World J Plast Surg. 2018 Jan;7(1):45-50.
The number of diabetic patients in adult population is increasing. All this population are at risk of developing diabetic foot ulcers (DFUs) that are associated with unwanted ailments and high mortality. In spite of current therapies for DFUs, further therapies are needed to help the patients.
The efficacy of herbal cream containing and essential oils was evaluated topically for treatment of DFUs in rat animal model in comparison with two other herbal formulas containing each essential oil alone, placebo (the basic formula without active ingredients) and normal saline as control groups. After anesthesia of diabetic rats (n=75) induced by streptozotocin (STZ), diabetic wounds were visible on the hind dorsal surface . The treatments were initiated on Day 1 and repeated 3 times a day for thirteen consecutive days. On day 1, 3, 5, 8 and 13, the wound sizes were determined and assessed histologically.
Three herbal formulations reduced the size of wounds in rats with DFUs, while the cream containing combined herbals of and essential oils had the highest tissue repair in DFU rat models.
Due to better wound healing effects of combined herbal cream containing and essential oils, it can be recommended in treatment of DFUs.
成年人群中糖尿病患者的数量正在增加。所有这些人群都有发生糖尿病足溃疡（DFU）的风险，糖尿病足溃疡与不良疾病和高死亡率相关。尽管目前有针对DFU的治疗方法，但仍需要进一步的治疗来帮助患者。
与另外两种分别仅含一种精油的草药配方、安慰剂（不含活性成分的基础配方）和生理盐水作为对照组相比，在大鼠动物模型中局部评估含有[具体成分1]和[具体成分2]精油的草药乳膏治疗DFU的疗效。用链脲佐菌素（STZ）诱导糖尿病大鼠（n = 75）麻醉后，在其背部后表面可见糖尿病伤口。治疗于第1天开始，连续13天每天重复3次。在第1、3、5、8和13天，测定伤口大小并进行组织学评估。
三种草药配方均减小了DFU大鼠的伤口大小，而含有[具体成分1]和[具体成分2]精油组合草药的乳膏在DFU大鼠模型中具有最高的组织修复率。
由于含有[具体成分1]和[具体成分2]精油的组合草药乳膏具有更好的伤口愈合效果，因此可推荐用于治疗DFU。
