Yamada Yuta, Nakagawa Tohru, Sugihara Toru, Horiuchi Takamasa, Yoshizaki Uran, Fujimura Tetsuya, Fukuhara Hiroshi, Urano Tomohiko, Takayama Kenichi, Inoue Satoshi, Kume Haruki, Homma Yukio
Department of Urology, Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Tokyo, Japan.
Department of Geriatric Medicine and Anti-Aging Medicine, Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Tokyo, Japan.
BMC Cancer. 2016 Nov 18;16(1):898. doi: 10.1186/s12885-016-2926-5.
Prognostic value of immune cells is not clear in testicular germ cell tumors (TGCTs). We aimed to investigate the prognostic value of tumor-infiltrating neutrophils in TGCTs.
A total of 102 patients who underwent orchiectomy for TGCT were investigated for CD66b positive tumor-infiltrating neutrophils (CD66b + TINs). Immmunostaining for CD66b was performed in 102 sections as described. Clinicopathological parameters as well as cancer specific survival and overall survival were assessed for correlation with CD66b + TIN density.
High density group was significantly correlated with tumor diameter ≥ 10 cm, presence of nodal/distant metastasis, S stage, diagnosis of nonseminomatous germ cell tumor (NGCT), and presence of venous invasion (p = 0.0198, p < 0.0001, p = 0.0275, p = 0.0004, and p = 0.0287, respectively). It was also significantly associated with cancer-specific and overall survival (logrank p = 0.0036, and p = 0.0002, respectively). Multivariate analysis showed that increased CD66b + TIN was an independent prognostic factor for overall survival (p = 0.0095).
Increased CD66b + TIN was significantly associated with presence of metastasis, S stage, and nonseminomatous germ cell tumor diagnosis. It was also an independent prognostic factor of overall survival in patients with TGCT.
免疫细胞在睾丸生殖细胞肿瘤（TGCT）中的预后价值尚不清楚。我们旨在研究肿瘤浸润性中性粒细胞在TGCT中的预后价值。
对102例行睾丸切除术的TGCT患者进行CD66b阳性肿瘤浸润性中性粒细胞（CD66b + TINs）检测。按照所述方法对102个切片进行CD66b免疫染色。评估临床病理参数以及癌症特异性生存率和总生存率与CD66b + TIN密度的相关性。
高密度组与肿瘤直径≥10 cm、存在淋巴结/远处转移、S分期、非精原细胞性生殖细胞肿瘤（NGCT）诊断以及存在静脉侵犯显著相关（分别为p = 0.0198、p < 0.0001、p = 0.0275、p = 0.0004和p = 0.0287）。它还与癌症特异性生存率和总生存率显著相关（对数秩检验p分别为0.0036和0.0002）。多因素分析显示，CD66b + TIN增加是总生存的独立预后因素（p = 0.0095）。
CD66b + TIN增加与转移的存在、S分期和非精原细胞性生殖细胞肿瘤诊断显著相关。它也是TGCT患者总生存的独立预后因素。
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