Archer Tenley C, Fertig Elana J, Gosline Sara J C, Hafner Marc, Hughes Shannon K, Joughin Brian A, Meyer Aaron S, Piccolo Stephen R, Shajahan-Haq Ayesha N
Department of Neurology, Boston Children's Hospital, Boston, Massachusetts.
Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, Maryland.
Cancer Res. 2016 Dec 1;76(23):6774-6777. doi: 10.1158/0008-5472.CAN-16-1580. Epub 2016 Nov 18.
Cancer systems biology aims to understand cancer as an integrated system of genes, proteins, networks, and interactions rather than an entity of isolated molecular and cellular components. The inaugural Systems Approaches to Cancer Biology Conference, cosponsored by the Association of Early Career Cancer Systems Biologists and the National Cancer Institute of the NIH, focused on the interdisciplinary field of cancer systems biology and the challenging cancer questions that are best addressed through the combination of experimental and computational analyses. Attendees found that elucidating the many molecular features of cancer inevitably reveals new forms of complexity and concluded that ensuring the reproducibility and impact of cancer systems biology studies will require widespread method and data sharing and, ultimately, the translation of important findings to the clinic. Cancer Res; 76(23); 6774-7. ©2016 AACR.
癌症系统生物学旨在将癌症理解为一个由基因、蛋白质、网络和相互作用组成的综合系统，而非孤立的分子和细胞成分的集合。由早期职业癌症系统生物学家协会和美国国立卫生研究院国家癌症研究所共同主办的首届癌症生物学系统方法会议，聚焦于癌症系统生物学这一跨学科领域，以及那些通过实验和计算分析相结合才能最佳解决的具有挑战性的癌症问题。与会者发现，阐明癌症的众多分子特征不可避免地揭示了新的复杂形式，并得出结论，确保癌症系统生物学研究的可重复性和影响力将需要广泛的方法和数据共享，最终还需要将重要发现转化到临床应用中。《癌症研究》；76(23)；6774 - 7。©2016美国癌症研究协会。
