Fox P T, Mintun M A
Department of Neurology and Neurosurgery, Mallinckrodt Institute of Radiology, McDonnell Center for Studies of Higher Brain Function, Washington University School of Medicine, St. Louis, Missouri.
J Nucl Med. 1989 Feb;30(2):141-9.
Change-distribution analysis and intersubject averaging of subtracted positron emission tomography (PET) images are new techniques for detecting, localizing, and quantifying state-dependent focal transients in neuronal activity. We previously described their application to cerebral blood flow images (intravenous bolus H215O, Kety autoradiographic model). We now describe their application to images of H215O regional tissue activity without conversion to units of blood flow. The sensitivity and specificity of response detection and the accuracy of response localization were virtually identical for the two types of images. Response magnitude expressed in percent change from rest was slightly, but consistently smaller in tissue-activity images. Response magnitude expressed in z-score was the same for the two-image types. Most research and clinical applications of functional brain mapping can employ images of H215O tissue activity (intravenous bolus, 40-sec nondynamic scan) without conversion to units of blood flow. This eliminates arterial blood sampling, thereby simplifying and minimizing the invasivity of the PET procedure.
减法正电子发射断层扫描（PET）图像的变化分布分析和受试者间平均是用于检测、定位和量化神经元活动中状态依赖性局灶性瞬变的新技术。我们之前描述了它们在脑血流图像（静脉推注H215O，凯蒂自显影模型）中的应用。我们现在描述它们在H215O区域组织活动图像中的应用，而无需转换为血流单位。两种类型图像在反应检测的敏感性和特异性以及反应定位的准确性方面几乎相同。以相对于静息的百分比变化表示的反应幅度在组织活动图像中略小，但始终如此。以z分数表示的反应幅度在两种图像类型中相同。大多数功能性脑图谱的研究和临床应用可以采用H215O组织活动图像（静脉推注，40秒非动态扫描），而无需转换为血流单位。这消除了动脉血采样，从而简化并最小化了PET程序的侵入性。
