Dubińska-Magiera Magda, Daczewska Małgorzata, Lewicka Anna, Migocka-Patrzałek Marta, Niedbalska-Tarnowska Joanna, Jagla Krzysztof
Department of Animal Developmental Biology, Institute of Experimental Biology, University of Wroclaw, 21 Sienkiewicza Street, 50-335 Wroclaw, Poland.
GReD-Genetics, Reproduction and Development Laboratory, INSERM U1103, CNRS UMR6293, University of Clermont-Auvergne, 28 Place Henri-Dunant, 63000 Clermont-Ferrand, France.
Int J Mol Sci. 2016 Nov 19;17(11):1941. doi: 10.3390/ijms17111941.
The rapid progress in medicine, agriculture, and allied sciences has enabled the development of a large amount of potentially useful bioactive compounds, such as drugs and pesticides. However, there is another side of this phenomenon, which includes side effects and environmental pollution. To avoid or minimize the uncontrollable consequences of using the newly developed compounds, researchers seek a quick and effective means of their evaluation. In achieving this goal, the zebrafish () has proven to be a highly useful tool, mostly because of its fast growth and development, as well as the ability to absorb the molecules diluted in water through its skin and gills. In this review, we focus on the reports concerning the application of zebrafish as a model for assessing the impact of toxicants on skeletal muscles, which share many structural and functional similarities among vertebrates, including zebrafish and humans.
医学、农业及相关科学领域的快速发展催生了大量具有潜在用途的生物活性化合物，如药物和杀虫剂。然而，这一现象也有另一面，包括副作用和环境污染。为避免或尽量减少使用新开发化合物带来的不可控后果，研究人员寻求一种快速有效的评估方法。在实现这一目标的过程中，斑马鱼已被证明是一种非常有用的工具，主要是因为它生长发育迅速，并且能够通过皮肤和鳃吸收水中稀释的分子。在这篇综述中，我们重点关注有关将斑马鱼作为模型评估有毒物质对骨骼肌影响的报告，斑马鱼和人类等脊椎动物的骨骼肌在结构和功能上有许多相似之处。
