实验性脑膜炎期间流感嗜血杆菌外膜囊泡诱导的血脑屏障通透性
Haemophilus influenzae outer membrane vesicle-induced blood-brain barrier permeability during experimental meningitis.
作者信息
Wispelwey B, Hansen E J, Scheld W M
机构信息
Department of Internal Medicine, University of Virginia School of Medicine, Charlottesville 22908.
出版信息
Infect Immun. 1989 Aug;57(8):2559-62. doi: 10.1128/iai.57.8.2559-2562.1989.
Abstract
Haemophilus influenzae type b (Hib) lipopolysaccharide (LPS) may be present in the cerebrospinal fluid largely as part of outer membrane vesicles (OMV), which could possibly alter its activity. Similar to inoculation of purified Hib LPS, intracisternal inoculation of Hib OMV into adult rats resulted in dose- and time-dependent increases in blood-brain barrier permeability. Polymyxin B, but not an oligosaccharide-specific monoclonal antibody, significantly inhibited the activity of Hib OMV. No change in blood-brain barrier permeability occurred in leukopenic rats inoculated with Hib OMV. Hib OMV was as active as purified Hib LPS on a weight basis and therefore appears to be a relevant vehicle for the delivery of LPS during meningitis.
摘要
b型流感嗜血杆菌（Hib）脂多糖（LPS）在脑脊液中可能主要以外膜囊泡（OMV）的形式存在，这可能会改变其活性。与接种纯化的Hib LPS相似，向成年大鼠脑池内接种Hib OMV会导致血脑屏障通透性呈剂量和时间依赖性增加。多粘菌素B可显著抑制Hib OMV的活性，而寡糖特异性单克隆抗体则不能。接种Hib OMV的白细胞减少大鼠的血脑屏障通透性没有变化。按重量计算，Hib OMV与纯化的Hib LPS活性相当，因此似乎是脑膜炎期间LPS传递的相关载体。
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