Department of Radiology, Fudan University Shanghai Cancer Center, Shanghai 200032, China.
Lab of Low-Dimensional Materials Chemistry, Key Laboratory for Ultrafine Materials of Ministry of Education, School of Materials Science and Engineering, East China University of Science and Technology, Shanghai 200237, China.
Nanoscale. 2016 Dec 1;8(47):19573-19580. doi: 10.1039/c6nr07062k.
In recent decades, hybrid imaging techniques that exploit the advantages of multiple imaging technologies have aroused extensive attention due to the deficiencies of single imaging modes. Along with the development of single photon emission computed tomography-magnetic resonance imaging (SPECT-MRI), it is currently necessary to develop a series of dual probes that can combine the outstanding sensitivity of SPECT with the high spatial resolution of MRI. Herein, the commonly used technetium-99 (Tc) was labelled on the surface of manganese oxide-based mesoporous silica nanoparticles (MnO-MSNs) for use in SPECT-MRI dual-modal imaging. The radiolabelling yield was as high as 99.1 ± 0.6%, and the r value of the nanoprobes was able to reach 6.60 mM s due to the pH-responsive properties of the MnO-MSNs. The high-performance SPECT-MRI dual-modal imaging was confirmed in vivo in tumour-bearing mice, which could also provide semi-quantitative information for tumour detection. Importantly, these nanoprobes can deliver anti-cancer drugs in cancer therapy due to their unique mesoporous structures. Thus, nanotheranostics combining dual-modal imaging with anti-cancer therapeutic properties were achieved.
近几十年来，由于单一成像模式的局限性，利用多种成像技术优势的混合成像技术引起了广泛关注。随着单光子发射计算机断层扫描-磁共振成像（SPECT-MRI）的发展，目前需要开发一系列能够将 SPECT 的优异灵敏度与 MRI 的高空间分辨率相结合的双探针。在此，将常用的锝-99（Tc）标记在基于氧化锰的介孔硅纳米粒子（MnO-MSNs）的表面上，用于 SPECT-MRI 双模成像。放射性标记产率高达 99.1±0.6%，由于 MnO-MSNs 的 pH 响应特性，纳米探针的 r 值能够达到 6.60mM s。在荷瘤小鼠中进行了高性能的 SPECT-MRI 双模成像，这也可以为肿瘤检测提供半定量信息。重要的是，由于其独特的介孔结构，这些纳米探针可以在癌症治疗中递送抗癌药物。因此，实现了将双模成像与抗癌治疗特性相结合的纳米治疗学。
