哮喘患者的日间过度嗜睡：危险因素有哪些？

Excessive daytime sleepiness in asthma: What are the risk factors?

作者信息

Kallin Sandra Andersson, Lindberg Eva, Sommar Johan Nilsson, Bossios Apostolos, Ekerljung Linda, Malinovschi Andrei, Middelveld Roelinde, Janson Christer

机构信息

a Department of Medical Sciences : Respiratory, Allergy and Sleep Research, Uppsala University , Uppsala , Sweden.

b Occupational and Environmental Medicine, Department of Public Health and Clinical Medicine , Umeå University , Umeå , Sweden.

出版信息

J Asthma. 2018 Aug;55(8):844-850. doi: 10.1080/02770903.2016.1263316. Epub 2018 Jul 23.

DOI:10.1080/02770903.2016.1263316

PMID:27880055

Abstract

OBJECTIVE

Previous studies have found that excessive daytime sleepiness (EDS) is a more common problem in asthmatic subjects than in the general population. The aim of this study was to investigate whether the prevalence of EDS is increased in asthmatic subjects and, if so, to analyse the occurrence of potential risk factors for EDS in asthmatics.

METHODS

Cross-sectional epidemiological study. In 2008, a postal questionnaire was sent out to a random sample of 45,000 individuals aged 16-75 years in four Swedish cities.

RESULTS

Of the 25,160 persons who participated, 7.3% were defined as having asthma. The prevalence of EDS was significantly higher in asthmatic subjects (42.1% vs. 28.5%, p < 0.001) compared with non-asthmatic subjects. Asthma was an independent risk factor for EDS (adjusted OR 1.29) and the risk of having EDS increased with asthma severity. Risk factors for EDS in subjects with asthma included insomnia (OR, 3.87; 95% CI, 3.10-4.84); chronic rhinosinusitis (OR, 2.00; 95% CI, 1.53-2.62); current smoking (OR, 1.60; 95% CI, 1.15-2.22) and obesity (OR, 1.53; 95% CI, 1.09-2.13).

CONCLUSIONS

EDS is a common problem among subjects with asthma. Asthma is an independent risk factor for having EDS. Furthermore, subjects with asthma often have other risk factors for EDS, many of them potentially modifiable.

摘要

目的

以往研究发现，与普通人群相比，白天过度嗜睡（EDS）在哮喘患者中是一个更常见的问题。本研究的目的是调查哮喘患者中EDS的患病率是否增加，如果增加，分析哮喘患者中EDS潜在危险因素的发生情况。

方法

横断面流行病学研究。2008年，向瑞典四个城市中年龄在16 - 75岁的45000名个体随机样本发放了邮政问卷。

结果

在参与的25160人中，7.3%被定义为患有哮喘。与非哮喘患者相比，哮喘患者中EDS的患病率显著更高（42.1%对28.5%，p < 0.001）。哮喘是EDS的独立危险因素（调整后的OR为1.29），且患EDS的风险随哮喘严重程度增加。哮喘患者中EDS的危险因素包括失眠（OR，3.87；95%CI，3.10 - 4.84）；慢性鼻 - 鼻窦炎（OR，2.00；95%CI，1.53 - 2.62）；当前吸烟（OR，1.60；95%CI，1.15 - 2.22）和肥胖（OR，1.53；95%CI，1.09 - 2.13）。