护士健康研究中苯二氮䓬受体激动剂与女性打鼾之间的关联

Association Between Benzodiazepine Receptor Agonists and Snoring Among Women in the Nurses' Health Study.

作者信息

Lin Brian M, Hu Frank B, Curhan Gary C

机构信息

Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, Boston2Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts3Harvard Medical School, Boston, Massachusetts.

Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts3Harvard Medical School, Boston, Massachusetts4Department of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, Massachusetts.

出版信息

JAMA Otolaryngol Head Neck Surg. 2017 Feb 1;143(2):162-167. doi: 10.1001/jamaoto.2016.3174.

DOI:10.1001/jamaoto.2016.3174

PMID:27893000

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5535073/

Abstract

IMPORTANCE

Snoring is highly prevalent among adults. The use of benzodiazepine receptor agonists is also common, with higher prevalence of use with more advanced age. Benzodiazepine receptor agonists cause muscle relaxation, which may affect muscle tone and airway dynamics and thereby increase snoring. Previous studies examining the association between use of benzodiazepine receptor agonists and snoring were underpowered to detect clinically meaningful differences or did not report the magnitude of association.

OBJECTIVE

To investigate the association between use of benzodiazepine receptor agonists and snoring in women.

DESIGN, SETTING, AND PARTICIPANTS: Women aged 62 to 86 years provided information on snoring and covariates of interest in the 2008 survey of the Nurses' Health Study, a cross-sectional cohort study of female registered nurses in the United States. Potential effect modification of the association between use of benzodiazepine receptor agonists and snoring by age, body mass index, waist circumference, smoking, alcohol consumption, and physical activity was explored. Logistic regression was used to adjust for potential confounders. Data analysis was conducted from November 2015 to March 2016.

MAIN OUTCOMES AND MEASURES

Self-reported habitual snoring, defined as a few nights a week or more.

RESULTS

Of 52 504 participants (mean [SD] age, 72.4 [6.7] years), 14 831 (28.2%) reported habitual snoring. There was a slightly higher prevalence of benzodiazepine receptor agonist use among habitual snorers (11.4%) compared with nonhabitual snorers (10.6%) (absolute difference, 0.8%; 95% CI, 0.2%-1.4%). After multivariable adjustment, use of benzodiazepine receptor agonists was not associated with snoring (odds ratio, 1.01; 95% CI, 0.95-1.07) compared with women who did not use benzodiazepine receptor agonists. Although there was no significant interaction with smoking, there were higher odds of snoring with use of benzodiazepine receptor agonists among current smokers (odds ratio, 1.34; 95% CI, 1.04-1.73).

CONCLUSIONS AND RELEVANCE

Use of benzodiazepine receptor agonists is not associated with odds of snoring in middle-aged and elderly women.

摘要

重要性

打鼾在成年人中极为普遍。苯二氮䓬受体激动剂的使用也很常见，且随着年龄增长使用 prevalence 更高。苯二氮䓬受体激动剂会导致肌肉松弛，这可能会影响肌张力和气道动力学，从而加重打鼾。先前研究苯二氮䓬受体激动剂使用与打鼾之间关联的研究，在检测具有临床意义的差异方面能力不足，或者未报告关联强度。

目的

研究苯二氮䓬受体激动剂的使用与女性打鼾之间的关联。

设计、设置和参与者：62至86岁的女性在2008年护士健康研究调查中提供了关于打鼾及相关协变量的信息，该研究是一项针对美国女性注册护士的横断面队列研究。探讨了年龄、体重指数、腰围、吸烟、饮酒和身体活动对苯二氮䓬受体激动剂使用与打鼾之间关联的潜在效应修正。采用逻辑回归调整潜在混杂因素。数据分析于2015年11月至2016年3月进行。

主要结局和测量指标

自我报告的习惯性打鼾，定义为每周几个晚上或更多。

结果

在52504名参与者（平均[标准差]年龄为72.4[6.7]岁）中，14831名（28.2%）报告有习惯性打鼾。习惯性打鼾者中苯二氮䓬受体激动剂的使用 prevalence（11.4%）略高于非习惯性打鼾者（10.6%）（绝对差异为0.8%；95%置信区间为0.2%-1.4%）。多变量调整后，与未使用苯二氮䓬受体激动剂的女性相比，使用苯二氮䓬受体激动剂与打鼾无关联（优势比为1.01；95%置信区间为0.95-1.07）。尽管与吸烟无显著交互作用，但当前吸烟者中使用苯二氮䓬受体激动剂时打鼾的几率更高（优势比为1.34；95%置信区间为1.04-1.73）。