Al-Hail Noora, Butler Alexandra E, Dargham Soha R, Abou Seif Ahmed, Atkin Stephen L
Research Faculty, Weill Cornell Medicine, Doha, Qatar.
Diabetes Research Center, Qatar Biomedical Research Institute, Hamad Bin Khalifa University, Qatar Foundation, Doha, Qatar.
Front Endocrinol (Lausanne). 2019 Sep 25;10:659. doi: 10.3389/fendo.2019.00659. eCollection 2019.
To correlate features of metabolic syndrome with creatine kinase (CK) in women with and without polycystic ovary syndrome (PCOS). Comparative cross-sectional analysis. Demographic and metabolic data from Qatari women aged 18-40 years from the Qatar Biobank (97 diagnosed with PCOS, 563 controls). The primary outcome was the association between plasma CK and features of metabolic syndrome. CK increased when the waist circumference was >80 cm ( < 0.015) and when associated with 2 or more features of the metabolic syndrome ( < 0.01). CK correlated with BMI ( < 0.003) but not with waist/hip ratio. Overall, CK did not differ between PCOS and controls, rising equally in both as body mass index (BMI) increased. C reactive protein (CRP) was higher in obese PCOS ( < 0.05) compared to controls, but did not correlate with CK ( > 0.05). CK was associated with an increase in BMI, waist circumference >80 cm and 2 or more features of the metabolic syndrome, in accord with the central role of type II skeletal muscle fibers in energy metabolism and obesity. CK was, however, independent of the PCOS phenotype.
在患有和未患有多囊卵巢综合征（PCOS）的女性中，将代谢综合征的特征与肌酸激酶（CK）进行关联分析。比较性横断面分析。来自卡塔尔生物样本库的18至40岁卡塔尔女性的人口统计学和代谢数据（97例被诊断为PCOS，563例为对照）。主要结局是血浆CK与代谢综合征特征之间的关联。当腰围>80 cm时（<0.015）以及与代谢综合征的2种或更多特征相关联时（<0.01），CK升高。CK与体重指数（BMI）相关（<0.003），但与腰臀比无关。总体而言，PCOS患者与对照组之间的CK无差异，随着体重指数（BMI）的增加，两者的CK均同样升高。与对照组相比，肥胖PCOS患者的C反应蛋白（CRP）更高（<0.05），但与CK不相关（>0.05）。CK与BMI增加、腰围>80 cm以及代谢综合征的2种或更多特征相关，这与II型骨骼肌纤维在能量代谢和肥胖中的核心作用一致。然而，CK与PCOS表型无关。
