来自红树林真菌的三种新二肽和两种新聚酮衍生物：两种分离物质的抗氧化活性
Three New Dipeptide and Two New Polyketide Derivatives from the Mangrove-Derived Fungus sp.: Antioxidant Activity of Two Isolated Substances.
作者信息
Zeng Zhihao, Cai Jian, Chen Yi, Li Xinlong, Chen Chunmei, Liu Yonghong, Jayasinghe Lalith, Zhou Xuefeng
机构信息
CAS Key Laboratory of Tropical Marine Bio-resources and Ecology/Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China.
University of Chinese Academy of Sciences, Beijing 100049, China.
出版信息
Mar Drugs. 2024 Dec 14;22(12):559. doi: 10.3390/md22120559.
Five new metabolites, including three cyclic dipeptide derivatives (-) and two new polyketides (-), together with nine known ones (- and -), were isolated from the mangrove-sediments-derived fungus sp. SCSIO 41431. Their structures were determined using detailed NMR, MS spectroscopic analyses, and quantum chemical calculations. X-ray single-crystal diffraction analysis of was described. Compounds - demonstrated activity against , with MIC values ranging from 25 to 50 µg/mL. Compound showed activity against , , and , with an MIC value of 100 µg/mL. In addition, compounds and showed DPPH radical scavenging activity, with the EC of 27.62 and 29.34 µg/mL, compared to the positive control (ascorbic acid, EC, 12.74 µg/mL).
从源自红树林沉积物的真菌sp. SCSIO 41431中分离出5种新的代谢产物，包括3种环二肽衍生物（-）和2种新的聚酮化合物（-），以及9种已知的代谢产物（-和-）。通过详细的核磁共振（NMR）、质谱（MS）光谱分析和量子化学计算确定了它们的结构。描述了化合物的X射线单晶衍射分析。化合物-对表现出活性，最小抑菌浓度（MIC）值范围为25至50μg/mL。化合物对、和表现出活性，MIC值为100μg/mL。此外，化合物和表现出二苯基苦味酰基自由基（DPPH）清除活性，半数有效浓度（EC）分别为27.62和29.34μg/mL，而阳性对照（抗坏血酸，EC为12.74μg/mL）。
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