MacLennan K A, Bennett M H, Tu A, Hudson B V, Easterling M J, Hudson G V, Jelliffe A M
Department of Histopathology, University Hospital, Nottingham, England.
Cancer. 1989 Oct 15;64(8):1686-93. doi: 10.1002/1097-0142(19891015)64:8<1686::aid-cncr2820640822>3.0.co;2-i.
Nodular sclerosing (NS) Hodgkin's disease (HD) with extensive areas of lymphocyte depletion or with numerous anaplastic Hodgkin's cells, termed Grade II NS, is associated with a poor response to initial therapy, an increased relapse rate, and decreased survival when compared with other NS variants, termed Grade I NS. The histopathologic subdivision of NS HD into Grade I and Grade II is easy to perform and provides essential prognostic information that is independent of stage. Patients with Grade II NS HD may require more aggressive initial therapy if their survival is to be improved.
结节硬化型（NS）霍奇金淋巴瘤（HD）伴有广泛淋巴细胞消减区域或有大量间变性霍奇金细胞，称为Ⅱ级NS，与其他NS亚型（称为Ⅰ级NS）相比，其对初始治疗反应较差、复发率增加且生存率降低。将NS HD组织病理学细分为Ⅰ级和Ⅱ级易于操作，并提供独立于分期的重要预后信息。如果要提高生存率，Ⅱ级NS HD患者可能需要更积极的初始治疗。
