MMWR Morb Mortal Wkly Rep. 2016 Dec 2;65(47):1332-1335. doi: 10.15585/mmwr.mm6547a2.
The World Health Organization (WHO) recommends viral load testing as the preferred method for monitoring the clinical response of patients with human immunodeficiency virus (HIV) infection to antiretroviral therapy (ART) (1). Viral load monitoring of patients on ART helps ensure early diagnosis and confirmation of ART failure and enables clinicians to take an appropriate course of action for patient management. When viral suppression is achieved and maintained, HIV transmission is substantially decreased, as is HIV-associated morbidity and mortality (2). CDC and other U.S. government agencies and international partners are supporting multiple countries in sub-Saharan Africa to provide viral load testing of persons with HIV who are on ART. This report examines current capacity for viral load testing based on equipment provided by manufacturers and progress with viral load monitoring of patients on ART in seven sub-Saharan countries (Côte d'Ivoire, Kenya, Malawi, Namibia, South Africa, Tanzania, and Uganda) during January 2015-June 2016. By June 2016, based on the target numbers for viral load testing set by each country, adequate equipment capacity existed in all but one country. During 2015, two countries tested >85% of patients on ART (Namibia [91%] and South Africa [87%]); four countries tested <25% of patients on ART. In 2015, viral suppression was >80% among those patients who received a viral load test in all countries except Côte d'Ivoire. Sustained country commitment and a coordinated global effort is needed to reach the goal for viral load monitoring of all persons with HIV on ART.
世界卫生组织(WHO)建议将病毒载量检测作为监测人类免疫缺陷病毒(HIV)感染患者接受抗逆转录病毒治疗(ART)临床反应的首选方法(1)。ART 患者的病毒载量监测有助于确保早期诊断和确认 ART 失败,并使临床医生能够为患者管理采取适当的措施。当病毒得到抑制并得以维持时,HIV 传播会大大减少,HIV 相关发病率和死亡率也会降低(2)。美国疾病控制与预防中心(CDC)和其他美国政府机构以及国际合作伙伴正在支持撒哈拉以南非洲的多个国家为接受 ART 的 HIV 感染者提供病毒载量检测。本报告根据制造商提供的设备检查了目前的病毒载量检测能力,并审查了 2015 年 1 月至 2016 年 6 月期间 7 个撒哈拉以南非洲国家(科特迪瓦、肯尼亚、马拉维、纳米比亚、南非、坦桑尼亚和乌干达)接受 ART 的患者的病毒载量监测进展情况。截至 2016 年 6 月,根据各国设定的病毒载量检测目标数量,除一个国家外,所有国家都具备充足的设备能力。2015 年,有两个国家对超过 85%的接受 ART 的患者进行了检测(纳米比亚[91%]和南非[87%]);有四个国家对不到 25%的接受 ART 的患者进行了检测。2015 年,除科特迪瓦外,所有接受病毒载量检测的患者中,病毒抑制率均超过 80%。为了实现对所有接受 ART 的 HIV 感染者进行病毒载量监测的目标,需要各国持续承诺并开展全球协调努力。