费城阴性慢性髓细胞白血病慢性期的8号染色体三体

Trisomy 8 in the chronic phase of Philadelphia negative chronic myelocytic leukaemia.

作者信息

Lindquist R, Gahrton G, Friberg K, Zech L

出版信息

Scand J Haematol. 1978 Aug;21(2):109-14. doi: 10.1111/j.1600-0609.1978.tb02501.x.

DOI:10.1111/j.1600-0609.1978.tb02501.x

Abstract

An unusual case of Philadelphia negative chronic myelocytic leukaemia and an extra chromosome 8 in all bone marrow cells is described. The abnormality was present at diagnosis of the disease and throughout the chronic phase which lasted for somewhat less than 2 years. The patient died soon after the blastic transformation with no other chromosomal abnormalities.

摘要

描述了一例不寻常的费城染色体阴性慢性粒细胞白血病病例，所有骨髓细胞中均存在一条额外的8号染色体。该异常在疾病诊断时就已存在，并贯穿了持续不到2年的慢性期。患者在急变后不久死亡，未发现其他染色体异常。