Powers Ann M
Division of Vector-Borne Diseases, Centers for Disease Control and Prevention, Fort Collins, Colorado.
J Infect Dis. 2016 Dec 15;214(suppl 5):S449-S452. doi: 10.1093/infdis/jiw382.
Chikungunya virus has been causing a series of ongoing epidemics around the globe for the past 12 years. During that time, estimates indicate that >4 million cases occurred worldwide. Despite the magnitude of these outbreaks and the broad interest in understanding the virus and disease, significant gaps still exist in our knowledge base. An in-depth understanding of the basic virological elements that can affect the epidemiology of the agent is critical for future development of control and treatment products. This work describes how knowledge of various viral genetic and structural elements has begun to advance the development of vaccines and therapeutics and suggests that further knowledge is needed to provide additional options.
在过去12年里，基孔肯雅病毒一直在全球引发一系列持续的疫情。在此期间，据估计全球发生了超过400万例病例。尽管这些疫情规模巨大，且人们对了解该病毒和疾病有着广泛兴趣，但我们的知识库中仍存在重大空白。深入了解可能影响该病原体流行病学的基本病毒学要素，对于未来控制和治疗产品的开发至关重要。这项工作描述了关于各种病毒遗传和结构要素的知识如何开始推动疫苗和治疗方法的开发，并表明需要更多知识来提供更多选择。
