Godaert Lidvine, Nicolon Camille, Najioullah Fatiha, Kanagaratnam Lukshe, Césaire Raymond, Dramé Moustapha
Department of Geriatrics, General Hospital of Valenciennes, Valenciennes, France.
Department of Geriatrics, Hospital of Marennes, Marennes, France.
Infect Drug Resist. 2020 Jul 10;13:2223-2228. doi: 10.2147/IDR.S253893. eCollection 2020.
The aim of this study was to investigate whether Chikungunya virus infection (CVI) was an independent risk factor for 2-year mortality in Afro-Caribbean subjects aged 65 years or older.
A retrospective cohort study was performed from January 2014 to December 2016 in the University Hospital of Martinique. Subjects aged ≥65 years admitted to the hospital were included. Baseline characteristics and concurrent manifestations at admission were collected. Subjects were followed up by phone for 2 years.
A total of 687 old Afro-Caribbean subjects (80.4±8.0 years) were included: 467 positive for CVI (Chik+) and 220 negative for CVI (Chik-). During the follow-up, 180 (26.2%) died. The proportion of deaths was higher among Chik- (40.9%) than among Chik+ subjects (21.6%) (p<0.0001). By multivariable analysis, when adjusted for age polyarthralgia, neurological troubles, cardiovascular disorders, absence of neutrophilia, thrombocytopenia, hypernatremia, and hospital stay, Chik+ subjects had significantly higher survival rates (HR: 0.58; 95% CI: 0.40-0.85) than Chik- ones.
Within the two years following hospital admission of subjects aged ≥65 years or older, Chik+ subjects had significantly higher survival rates than Chik- ones.
本研究旨在调查基孔肯雅病毒感染（CVI）是否为65岁及以上非洲加勒比裔受试者2年死亡率的独立危险因素。
2014年1月至2016年12月在马提尼克大学医院进行了一项回顾性队列研究。纳入年龄≥65岁入院的患者。收集入院时的基线特征和并发表现。通过电话对受试者进行2年随访。
共纳入687名非洲加勒比裔老年受试者（80.4±8.0岁）：467名CVI阳性（Chik+），220名CVI阴性（Chik-）。随访期间，180人（26.2%）死亡。Chik-组的死亡比例（40.9%）高于Chik+组（21.6%）（p<0.0001）。多变量分析显示，在调整年龄、多关节痛、神经问题、心血管疾病、无中性粒细胞增多、血小板减少、高钠血症和住院时间后，Chik+组受试者的生存率显著高于Chik-组（HR：0.58；95%CI：0.40-0.85）。
在65岁及以上受试者入院后的两年内，Chik+组受试者的生存率显著高于Chik-组。
