Birnbaum Faith A, Johnson Gabriella M, Johnson Lenworth N, Jun Bokkwan, Machan Jason T
Neuro-Ophthalmology Unit, Department of Ophthalmology, Alpert Medical School of Brown University/Lifespan/Rhode Island Hospital , Providence, Rhode Island, USA.
Neuro-Ophthalmology Unit, Mason Eye Institute, University of Missouri , Columbia, Missouri, USA.
Neuroophthalmology. 2016 Jul 1;40(4):171-180. doi: 10.1080/01658107.2016.1198917. eCollection 2016 Aug.
This is a 25-year observational retrospective review of 372 consecutive participants with optic disc drusen or resolved papilloedema from idiopathic intracranial hypertension. The prevalence of optic disc drusen at 19% among eyes with resolved papilloedema was approximately 10 times higher and significantly increased ( < 0.001) as compared with the occurrence in the general population. Eyes with both resolved papilloedema and optic disc drusen had similar visual acuity and visual field outcome as compared with resolved papilloedema alone. Eyes with exposed drusen had significantly worse visual acuity and visual field outcome ( < 0.001) than buried drusen. The high prevalence of optic disc drusen after papilloedema has resolved suggests a non-coincidental relationship. Optic disc drusen formation can be a sequela of papilloedema.
这是一项对372名患有视盘玻璃疣或特发性颅内高压所致视乳头水肿消退的连续参与者进行的25年观察性回顾研究。视乳头水肿消退的眼中视盘玻璃疣的患病率为19%，与普通人群中的发生率相比，大约高出10倍且显著增加（<0.001）。既有视乳头水肿消退又有视盘玻璃疣的眼睛与仅视乳头水肿消退的眼睛相比，视力和视野结果相似。玻璃疣暴露的眼睛与玻璃疣埋藏的眼睛相比，视力和视野结果显著更差（<0.001）。视乳头水肿消退后视盘玻璃疣的高患病率表明存在非偶然关系。视盘玻璃疣的形成可能是视乳头水肿的后遗症。
