Department of Ophthalmology, Seoul National University College of Medicine, Seoul, South Korea.
Am J Ophthalmol. 2013 Jun;155(6):1139-1147.e1. doi: 10.1016/j.ajo.2013.01.024. Epub 2013 Mar 19.
To evaluate the morphologic characteristics of optic nerve head drusen.
Retrospective case series.
setting: Institutional (Seoul National University Bundang Hospital). patients: Sixty-one patients with optic nerve head drusen. observation procedure: Visible and buried optic nerve head drusen were identified using funduscopy, whereas homogenous and nonhomogenous optic nerve head drusen were identified using spectral-domain optical coherence tomography images. Buried optic nerve head drusen were classified according to the size. main outcome measures: Classification of optic nerve head drusen.
Of 99 eyes in 61 patients, optic nerve head drusen were buried in 95 eyes and visible in 4 eyes. The patients with visible optic nerve head drusen were older on average than those with buried optic nerve head drusen (53.3 ± 8.6 years vs 13.5 ± 7.1 years; P < .001) and exhibited larger disc diameters (1643 ± 265 μm vs 1287 ± 185 μm; P = .016). All 4 eyes with visible optic nerve head drusen exhibited hyperreflective borders, which were not found in patients with buried optic nerve head drusen. Of 95 eyes with buried optic nerve head drusen, 64 eyes (67%) showed homogenous internal reflectivity, whereas 31 eyes (33%) showed nonhomogenous reflectivity with lobulations. Large optic nerve head drusen were associated with a small optic disc diameter, nonhomogenous internal reflectivity, a partial highly reflective border, intraretinal cysts, and increased temporal retinal nerve fiber layer thickness.
Optic nerve head drusen have a diverse spectrum of spectral-domain optical coherence tomography findings associated with patient age and disc size.
评估视神经乳头神经鞘瘤的形态特征。
回顾性病例系列。
机构设置（首尔大学盆唐医院）。
61 例视神经乳头神经鞘瘤患者。
眼底镜检查可识别可见和埋藏的视神经乳头神经鞘瘤，而光谱域光相干断层扫描图像可识别同质和非同质的视神经乳头神经鞘瘤。根据大小对埋藏性视神经乳头神经鞘瘤进行分类。
视神经乳头神经鞘瘤分类。
在 61 例患者的 99 只眼中，视神经乳头神经鞘瘤埋藏在 95 只眼中，可见在 4 只眼中。可见视神经乳头神经鞘瘤的患者平均年龄大于埋藏性视神经乳头神经鞘瘤患者（53.3 ± 8.6 岁比 13.5 ± 7.1 岁；P <.001），且视盘直径较大（1643 ± 265μm 比 1287 ± 185μm；P =.016）。4 只可见视神经乳头神经鞘瘤的眼均表现为高反射边界，而埋藏性视神经乳头神经鞘瘤患者则无此表现。在 95 只埋藏性视神经乳头神经鞘瘤眼中，64 只眼（67%）表现为均匀的内部反射性，31 只眼（33%）表现为具有分叶的非均匀反射性。大的视神经乳头神经鞘瘤与小的视盘直径、非均匀的内部反射性、部分高反射边界、视网膜内囊肿和增加的颞侧视网膜神经纤维层厚度有关。
视神经乳头神经鞘瘤的光谱域光相干断层扫描表现多样，与患者年龄和视盘大小有关。
