Weiner Michael W, Veitch Dallas P, Aisen Paul S, Beckett Laurel A, Cairns Nigel J, Green Robert C, Harvey Danielle, Jack Clifford R, Jagust William, Morris John C, Petersen Ronald C, Salazar Jennifer, Saykin Andrew J, Shaw Leslie M, Toga Arthur W, Trojanowski John Q
Department of Veterans Affairs Medical Center, Center for Imaging of Neurodegenerative Diseases, San Francisco, CA, USA; Department of Radiology, University of California, San Francisco, CA, USA; Department of Medicine, University of California, San Francisco, CA, USA; Department of Psychiatry, University of California, San Francisco, CA, USA; Department of Neurology, University of California, San Francisco, CA, USA.
Department of Veterans Affairs Medical Center, Center for Imaging of Neurodegenerative Diseases, San Francisco, CA, USA.
Alzheimers Dement. 2017 May;13(5):561-571. doi: 10.1016/j.jalz.2016.10.006. Epub 2016 Dec 5.
The overall goal of the Alzheimer's Disease Neuroimaging Initiative (ADNI) is to validate biomarkers for Alzheimer's disease (AD) clinical trials. ADNI-3, which began on August 1, 2016, is a 5-year renewal of the current ADNI-2 study.
ADNI-3 will follow current and additional subjects with normal cognition, mild cognitive impairment, and AD using innovative technologies such as tau imaging, magnetic resonance imaging sequences for connectivity analyses, and a highly automated immunoassay platform and mass spectroscopy approach for cerebrospinal fluid biomarker analysis. A Systems Biology/pathway approach will be used to identify genetic factors for subject selection/enrichment. Amyloid positron emission tomography scanning will be standardized using the Centiloid method. The Brain Health Registry will help recruit subjects and monitor subject cognition.
Multimodal analyses will provide insight into AD pathophysiology and disease progression.
ADNI-3 will aim to inform AD treatment trials and facilitate development of AD disease-modifying treatments.
阿尔茨海默病神经影像学计划(ADNI)的总体目标是验证用于阿尔茨海默病(AD)临床试验的生物标志物。ADNI-3于2016年8月1日启动,是当前ADNI-2研究的5年延续。
ADNI-3将使用诸如tau成像、用于连通性分析的磁共振成像序列以及用于脑脊液生物标志物分析的高度自动化免疫测定平台和质谱方法等创新技术,对认知正常、轻度认知障碍和AD的现有及新增受试者进行跟踪研究。将采用系统生物学/通路方法来识别用于受试者选择/富集的遗传因素。淀粉样蛋白正电子发射断层扫描将使用Centiloid方法进行标准化。脑健康登记处将有助于招募受试者并监测受试者的认知情况。
多模态分析将深入了解AD的病理生理学和疾病进展。
ADNI-3旨在为AD治疗试验提供信息,并促进AD疾病修饰治疗的开发。