Wang Cong, Guo Lei, Hao Jiejie, Wang Liping, Zhu Weiming
Key Laboratory of Marine Drugs, Ministry of Education of China, School of Medicine and Pharmacy, Ocean University of China , Qingdao 266003, People's Republic of China.
Jiangsu Marine Resources Development Research Institute, School of Marine Life and Fisheries, Huaihai Institute of Technology , Lianyungang 222004, People's Republic of China.
J Nat Prod. 2016 Nov 23;79(11):2977-2981. doi: 10.1021/acs.jnatprod.6b00766. Epub 2016 Nov 14.
Three new butenolide derivatives, flavipesolides A-C (1-3), along with 13 known compounds (4-13, aspulvinone Q, monochlorosulochrin, and dihydrogeodin), were isolated from the marine-derived Aspergillus flavipes HN4-13 from a Lianyungang coastal sediment sample. The structures were elucidated by spectroscopic evidence. Compounds 4-6 and 9 were noncompetitive α-glucosidase inhibitors with K/IC values of 0.43/34, 2.1/37, 0.79/19, and 2.8/90 μM, respectively. Compounds 1-3, 8, 10, and 13 are mixed α-glucosidase inhibitors with K/IC values of (2.5, 19)/44, (3.4, 14)/57, (9.2, 4.7)/95, (6.3, 5.5)/55, (1.4, 0.60)/9.9, and (2.5, 7.2)/33 μM, respectively (IC 101 μM for acarbose and 79 μM for 1-deoxynojirimycin).
从连云港沿海沉积物样本中分离得到的海洋来源黄柄曲霉HN4-13中，鉴定出三种新的丁烯内酯衍生物，即黄柄曲霉内酯A-C（1-3），以及13种已知化合物（4-13，曲霉醌、一氯苏罗克菌素和二氢戈地因）。通过光谱数据对其结构进行了鉴定。化合物4-6和9为非竞争性α-葡萄糖苷酶抑制剂，其K/IC值分别为0.43/34、2.1/37、0.79/19和2.8/90 μM。化合物1-3、8、10和13为混合型α-葡萄糖苷酶抑制剂，其K/IC值分别为(2.5, 19)/44、(3.4, 14)/57、(9.2, 4.7)/95、(6.3, 5.5)/55、(1.4, 0.60)/9.9和(2.5, 7.2)/33 μM（阿卡波糖的IC为101 μM，1-脱氧野尻霉素的IC为79 μM）。
