钯催化的丙炔碳酸酯与异氰化物的多组分反应（MCR）。
Palladium-Catalyzed Multicomponent Reaction (MCR) of Propargylic Carbonates with Isocyanides.
机构信息
Key Laboratory of Functional Molecular Engineering of Guangdong Province, School of Chemistry and Chemical Engineering, South China University of Technology , Guangzhou 510640, P. R. China.
出版信息
Org Lett. 2016 Nov 18;18(22):5924-5927. doi: 10.1021/acs.orglett.6b02999. Epub 2016 Nov 10.
A palladium-catalyzed multicomponent reaction (MCR) of propargylic carbonates with isocyanides is reported. Remarkably, the orderly insertion of isocyanides affords two types of valuable N-heterocyclic products (Z)-6-imino-4,6-dihydro-1H-furo[3,4-b]pyrrol-2-amines and (E)-5-iminopyrrolones in high yields. Systematic analysis of the reaction conditions indicates that the selectivity of these N-heterocyclic products can be controlled by ligands and temperature.
报道了钯催化的丙炔碳酸酯与异氰化物的多组分反应（MCR）。值得注意的是，异氰化物的有序插入提供了两种有价值的 N-杂环产物（Z）-6-亚氨基-4,6-二氢-1H-呋喃[3,4-b]吡咯-2-胺和（E）-5-亚氨基吡咯烷酮，产率很高。对反应条件的系统分析表明，这些 N-杂环产物的选择性可以通过配体和温度来控制。
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