Lyon J P, Carvalho C R, Rezende R R, Lima C J, Santos F V, Moreira L M
Department of Natural Sciences, Campus Centro-Oeste D. Lindu, Universidade Federal de São João Del Rei, São João Del Rei, São Paulo, Brazil.
Department of Animal Science, Instituto de Engenharia Biomédica, Universidade Camilo Castelo Branco, São Paulo, Brazil.
Indian J Med Microbiol. 2016 Oct-Dec;34(4):506-508. doi: 10.4103/0255-0857.195351.
Photodynamic therapy (PDT) has been proved to be effective against fungi and it may be employed as a coadjutant to conventional antifungal agents, leading to a more effective microbial control minimising side effects. This work evaluates the combined effect of PDT and fluconazole against resistant Candida albicans, Candida glabrata and Candida krusei. The yeasts were submitted to methylene blue-PDT (MB-PDT) in sub-inhibitory concentrations. In the present work, MB-PDT combined with fluconazole was more efficient in the inhibition of the C. albicans and C. glabrata than each treatment alone, being possible to infer that the treatments are synergic.
光动力疗法（PDT）已被证明对真菌有效，它可以作为传统抗真菌药物的辅助手段，从而实现更有效的微生物控制并将副作用降至最低。这项研究评估了光动力疗法（PDT）与氟康唑联合使用对耐药白色念珠菌、光滑念珠菌和克柔念珠菌的综合效果。将这些酵母菌置于亚抑制浓度的亚甲蓝-光动力疗法（MB-PDT）中。在本研究中，MB-PDT联合氟康唑在抑制白色念珠菌和光滑念珠菌方面比单独使用每种治疗方法更有效，可以推断这些治疗方法具有协同作用。
