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Antibiotic discovery is a walk in the park.

作者信息

Nothias Louis-Félix, Knight Rob, Dorrestein Pieter C

机构信息

Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, CA 92093.

Collaborative Mass Spectrometry Innovation Center, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, CA 92093.

出版信息

Proc Natl Acad Sci U S A. 2016 Dec 20;113(51):14477-14479. doi: 10.1073/pnas.1618221114. Epub 2016 Dec 9.

DOI:10.1073/pnas.1618221114
PMID:27940910
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5187748/
Abstract
摘要

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Mycins v Microbes Missing Microbes: How the Overuse of Antibiotics Is Fueling Our Modern Plagues by Martin J. Blaser (2014) Holt New York, USA.《霉菌与微生物 缺失的微生物：抗生素的过度使用如何引发现代瘟疫》 作者：马丁·J·布莱泽（2014年） 美国纽约霍尔特出版社
FASEB J. 2014 Sep;28(9):3821-3822. doi: 10.1096/fj.14-0901ufm.
2
Urban park soil microbiomes are a rich reservoir of natural product biosynthetic diversity.城市公园土壤微生物群落是天然产物生物合成多样性的丰富宝库。
Proc Natl Acad Sci U S A. 2016 Dec 20;113(51):14811-14816. doi: 10.1073/pnas.1615581113. Epub 2016 Nov 28.
3
Sharing and community curation of mass spectrometry data with Global Natural Products Social Molecular Networking.通过全球天然产物社会分子网络共享和社区管理质谱数据。
Nat Biotechnol. 2016 Aug 9;34(8):828-837. doi: 10.1038/nbt.3597.
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Optimizing Metabolic Pathways for the Improved Production of Natural Products.优化代谢途径以提高天然产物的产量。
Methods Enzymol. 2016;575:179-93. doi: 10.1016/bs.mie.2016.02.010. Epub 2016 Mar 10.
5
New tools for reconstruction and heterologous expression of natural product biosynthetic gene clusters.天然产物生物合成基因簇的重建和异源表达新工具。
Nat Prod Rep. 2016 Feb;33(2):174-82. doi: 10.1039/c5np00085h.
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Reinvigorating natural product combinatorial biosynthesis with synthetic biology.用合成生物学重振天然产物组合生物合成。
Nat Chem Biol. 2015 Sep;11(9):649-59. doi: 10.1038/nchembio.1893.
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Discovery of microbial natural products by activation of silent biosynthetic gene clusters.微生物天然产物的发现：沉默生物合成基因簇的激活。
Nat Rev Microbiol. 2015 Aug;13(8):509-23. doi: 10.1038/nrmicro3496. Epub 2015 Jun 29.
8
The antibiotic resistance crisis: part 1: causes and threats.抗生素耐药性危机：第一部分：成因与威胁。
P T. 2015 Apr;40(4):277-83.
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A new antibiotic and the evolution of resistance.一种新型抗生素与耐药性的演变
N Engl J Med. 2015 Mar 19;372(12):1168-70. doi: 10.1056/NEJMcibr1500292.
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The re-emergence of natural products for drug discovery in the genomics era.基因组学时代天然产物在药物发现中的再兴起。
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