Chen Hong Bin, Huang Yue, Song Hui Wen, Li Xiao Lin, He Song, Xie Jia Tia, Huang Chun, Zhang Sheng Jun, Liu Jia, Zou Ying
Department of Gastroenterology, Sanming First Affiliated Hospital of Fujian Medical University, Sanming 365000, China.
Department of Gastroenterology, the 2nd Affiliated Hospital of Chongqing Medical University, Chongqing 400010, China.
Gastroenterology Res. 2010 Feb;3(1):19-24. doi: 10.4021/gr2010.02.168w. Epub 2010 Jan 20.
Constipation is a common clinical symptom but its etiology remains unknown. The aims of the study are to discuss the relation between body mass index (BMI), motilin and the slow transit constipation (STC).
A total of 178 patients with STC and 123 healthy volunteers as controls were divided into three groups according to the BMI, group A (BMI <20), group B (BMI 20-25), and group C (BMI > 25). Fasting and one hour postprandial plasma motilin were measured and the results were analyzed.
There was significant difference in the constituent ratio between STC patients and healthy controls (p < 0.05). The percentage of group A, B and C in STC patients was 49.4% (88/178), 23.0% (41/178) and 27.6% (49/178), respectively; and group A had a higher percentage. Plasma motilin of fasting and one hour postprandial in STC patients of group A was significantly lower than that of group B and C (p < 0.05), but there was no difference between group B and C (p > 0.05). There was no significant difference in the results of plasma motilin of fasting and one hour postprandial among the three groups of healthy controls (p > 0.05). Plasma motilin of fasting and one hour postprandial in STC patients of group A was significantly lower than those healthy controls of group A (p < 0.05). The same results of plasma motilin of fasting and one hour postprandial could be seen in group B and C, respectively (p < 0.05).
A higher proportion of low BMI sufferers was found in the STC patients. The reason may be related to the lower release of the plasma motilin.
便秘是一种常见的临床症状，但其病因尚不清楚。本研究旨在探讨体重指数（BMI）、胃动素与慢传输型便秘（STC）之间的关系。
将178例STC患者和123例健康志愿者作为对照，根据BMI分为三组，A组（BMI<20）、B组（BMI 20-25）和C组（BMI>25）。测量空腹及餐后1小时血浆胃动素水平并分析结果。
STC患者与健康对照的构成比有显著差异（p<0.05）。STC患者中A组、B组和C组的比例分别为49.4%（88/178）、23.0%（41/178）和27.6%（49/178）；A组比例更高。A组STC患者空腹及餐后1小时血浆胃动素水平显著低于B组和C组（p<0.05），但B组和C组之间无差异（p>0.05）。三组健康对照者空腹及餐后1小时血浆胃动素水平结果无显著差异（p>0.05）。A组STC患者空腹及餐后1小时血浆胃动素水平显著低于A组健康对照者（p<0.05）。B组和C组也分别出现空腹及餐后1小时血浆胃动素的相同结果（p<0.05）。
STC患者中低BMI者比例较高。原因可能与血浆胃动素释放较低有关。
