Aster Jon C, Pear Warren S, Blacklow Stephen C
Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115; email:
Department of Pathology and Laboratory Medicine, Abramson Family Cancer Research Institute, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania 19104.
Annu Rev Pathol. 2017 Jan 24;12:245-275. doi: 10.1146/annurev-pathol-052016-100127. Epub 2016 Dec 5.
Notch receptors influence cellular behavior by participating in a seemingly simple signaling pathway, but outcomes produced by Notch signaling are remarkably varied depending on signal dose and cell context. Here, after briefly reviewing new insights into physiologic mechanisms of Notch signaling in healthy tissues and defects in Notch signaling that contribute to congenital disorders and viral infection, we discuss the varied roles of Notch in cancer, focusing on cell autonomous activities that may be either oncogenic or tumor suppressive.
Notch受体通过参与一个看似简单的信号通路来影响细胞行为，但Notch信号产生的结果会因信号剂量和细胞环境的不同而有显著差异。在此，在简要回顾了健康组织中Notch信号生理机制的新见解以及导致先天性疾病和病毒感染的Notch信号缺陷后，我们讨论了Notch在癌症中的多种作用，重点关注可能具有致癌或抑癌作用的细胞自主活动。
