Wu C T, Wang Y Z, Pei X T
Department of Experimental Hematology, Beijing Institute of Radiation Medicine, People's Republic of China.
Leuk Res. 1989;13(9):825-31. doi: 10.1016/0145-2126(89)90096-9.
In human fetal liver there are at least two kinds of cell growth suppressor, arginase and a low molecular weight suppressor, both are cytotoxic towards HL-60 cells under the condition of in vitro culture, and mainly present in the supernatant of fetal liver cell suspension. As compared with arginase, the low molecular weight suppressor shows a preferential suppression on HL-60 cell growth rather than that of granuloid-macrophage progenitors of normal human bone marrow.
在人类胎儿肝脏中至少存在两种细胞生长抑制因子，即精氨酸酶和一种低分子量抑制因子，在体外培养条件下，二者对HL-60细胞均具有细胞毒性，且主要存在于胎儿肝细胞悬液的上清液中。与精氨酸酶相比，低分子量抑制因子对HL-60细胞生长的抑制作用更为显著，而对正常人骨髓粒-巨噬系祖细胞的抑制作用较弱。
