Wang Chia-Woei, Hsu Wei-Hsuan, Tai Chen-Jei
Graduate Institute of Clinical Medicine, College of Medicine, Taipei Medical University, Taipei 11042, Taiwan.
Department of Obstetrics and Gynecology, School of Medicine, College of Medicine, Taipei Medical University, Taipei 11042, Taiwan.
Oncotarget. 2017 Jan 10;8(2):3049-3058. doi: 10.18632/oncotarget.13829.
Cordycepin (3'-deoxyadenosine) is a compound for antitumor, which has been found to exert antiangiogenic, antimetastatic, and antiproliferative effects, as well as inducing apoptosis. However, the association between cancer metastasis and mitochondrial activity in cordycepin-treated ovarian carcinoma cells remains unclear. The 50 and 100 μM of cordycepin inhibits mitochondrial fusion and induces mitochondrial fission, respectively. These suggested that cordycepin showed the down-regulation of mitochondrial function and limitation of energy production. Because of activation of mitochondria and generation of energy are needed in cancer cell migration/invasion. After 24 h treatment, cordycepin suppresses epithelial-mesenchymal transition and migration in ovarian carcinoma cells through inhibiting estrogen-related receptor (ERR)-α. The ERRα is a co-transcription factor for gene expressions associated with mitochondrial fusion. Our results indicate that cordycepin suppresses metastasis and migration of ovarian carcinoma cells via inhibiting mitochondrial activity in non-toxic concentrations, and cordycepin has potential benefits in ovarian cancer therapy.
虫草素（3'-脱氧腺苷）是一种抗肿瘤化合物，已发现它具有抗血管生成、抗转移和抗增殖作用，以及诱导细胞凋亡。然而，虫草素处理的卵巢癌细胞中癌症转移与线粒体活性之间的关联仍不清楚。50 μM和100 μM的虫草素分别抑制线粒体融合并诱导线粒体分裂。这些表明虫草素显示出线粒体功能的下调和能量产生的限制。因为癌细胞迁移/侵袭需要线粒体的激活和能量的产生。处理24小时后，虫草素通过抑制雌激素相关受体（ERR）-α来抑制卵巢癌细胞的上皮-间质转化和迁移。ERRα是与线粒体融合相关的基因表达的共转录因子。我们的结果表明，虫草素在无毒浓度下通过抑制线粒体活性来抑制卵巢癌细胞的转移和迁移，并且虫草素在卵巢癌治疗中具有潜在益处。
