一种由果蝇体节极性基因patched编码的、具有多个可能跨膜结构域的蛋白质。

A protein with several possible membrane-spanning domains encoded by the Drosophila segment polarity gene patched.

作者信息

Nakano Y, Guerrero I, Hidalgo A, Taylor A, Whittle J R, Ingham P W

机构信息

ICRF Developmental Biology Unit, Department of Zoology, Oxford, UK.

出版信息

Nature. 1989 Oct 12;341(6242):508-13. doi: 10.1038/341508a0.

DOI:10.1038/341508a0

PMID:2797178

Abstract

The patterning of cells in insect segments requires the exchange of information between cells, which in Drosophila depends on the activity of members of the segment-polarity class of genes. Here we report the molecular characterization of one such gene, patched. We find that patched encodes a large protein with several possible membrane-spanning domains and is expressed in a complex pattern during embryogenesis.

摘要

昆虫体节中细胞的模式形成需要细胞间进行信息交换，在果蝇中这依赖于体节极性类基因成员的活性。在此我们报告其中一个这样的基因——patched的分子特征。我们发现patched编码一种具有多个可能跨膜结构域的大蛋白，并且在胚胎发育过程中以复杂的模式表达。