Calabrese Edward J
Department of Environmental Health Sciences, School of Public Health and Health Sciences, Morrill I, N344, University of Massachusetts, Amherst, MA 01003, USA.
Environ Res. 2017 Apr;154:452-458. doi: 10.1016/j.envres.2016.11.024. Epub 2016 Dec 11.
This paper reveals that nearly 25 years after the National Academy of Sciences (NAS), Biological Effects of Ionizing Radiation (BEIR) I Committee (1972) used Russell's dose-rate data to support the adoption of the linear-no-threshold (LNT) dose response model for genetic and cancer risk assessment, Russell acknowledged a significant under-reporting of the mutation rate of the historical control group. This error, which was unknown to BEIR I, had profound implications, leading it to incorrectly adopt the LNT model, which was a decision that profoundly changed the course of risk assessment for radiation and chemicals to the present.
本文揭示，在美国国家科学院（NAS）电离辐射生物学效应（BEIR）I委员会（1972年）利用拉塞尔的剂量率数据支持采用线性无阈（LNT）剂量反应模型进行遗传和癌症风险评估近25年后，拉塞尔承认历史对照组的突变率存在重大漏报情况。BEIR I并不知晓这一错误，而它却产生了深远影响，导致其错误地采用了LNT模型，这一决定深刻地改变了至今辐射和化学品风险评估的进程。
