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成人呼吸内科病房耐9V型肺炎链球菌的医院内暴发

Nosocomial Outbreak of Drug-Resistant Streptococcus pneumoniae Serotype 9V in an Adult Respiratory Medicine Ward.

作者信息

Jauneikaite Elita, Khan-Orakzai Zareena, Kapatai Georgia, Bloch Susannah, Singleton Julie, Atkin Sara, Shah Victoria, Hatcher James, Samarasinghe Dunisha, Sheppard Carmen, Fry Norman K, Satta Giovanni, Sriskandan Shiranee

机构信息

Health Protection Research Unit in Healthcare Associated Infections and Antimicrobial Resistance, Imperial College London, London, United Kingdom.

Department of Medicine, Imperial College London, London, United Kingdom.

出版信息

J Clin Microbiol. 2017 Mar;55(3):776-782. doi: 10.1128/JCM.02405-16. Epub 2016 Dec 14.

DOI:10.1128/JCM.02405-16
PMID:27974539
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5328445/
Abstract

infections arising in hospitalized patients are often assumed to be sporadic and linked to community acquisition. Here, whole-genome sequencing was used to demonstrate nosocomial acquisition of antimicrobial-resistant sequence type 156 (ST156) serotype 9V in 3 respiratory patients that resulted in two bacteremias and one lower respiratory tract infection. Two of the cases arose in patients who had recently been discharged from the hospital and were readmitted from the community. Nosocomial spread was suspected solely because of the highly unusual resistance pattern and case presentations within 24 h of one another. The outbreak highlights the potential for rapid transmission and the short incubation period in the respiratory ward setting.

摘要

住院患者中出现的感染通常被认为是散发性的，且与社区感染有关。在此，全基因组测序被用于证明3例呼吸道患者发生了耐抗菌药物的序列类型156（ST156）血清型9V的医院内感染，导致2例菌血症和1例下呼吸道感染。其中2例发生在近期出院后又从社区重新入院的患者身上。仅因耐药模式高度异常且病例在24小时内相继出现，怀疑存在医院内传播。此次疫情凸显了呼吸病房环境中快速传播的可能性和短潜伏期。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/42eb/5328445/13dc07fcbc3e/zjm9990953710002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/42eb/5328445/3c5fd48b41a6/zjm9990953710001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/42eb/5328445/13dc07fcbc3e/zjm9990953710002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/42eb/5328445/3c5fd48b41a6/zjm9990953710001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/42eb/5328445/13dc07fcbc3e/zjm9990953710002.jpg

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