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Ceftolozane-tazobactam activity against drug-resistant Enterobacteriaceae and Pseudomonas aeruginosa causing healthcare-associated infections in Australia and New Zealand: Report from an Antimicrobial Surveillance Program (2013-2015).头孢洛扎他唑巴坦对澳大利亚和新西兰引起医源性感染的耐药肠杆菌科和铜绿假单胞菌的活性：来自一个抗菌药物监测计划的报告（2013-2015 年）。
J Glob Antimicrob Resist. 2017 Sep;10:186-194. doi: 10.1016/j.jgar.2017.05.025. Epub 2017 Jul 19.
2
Effectiveness of a group B outer membrane vesicle meningococcal vaccine against gonorrhoea in New Zealand: a retrospective case-control study.新西兰 B 群脑膜炎球菌外膜囊泡疫苗预防淋病的效果：一项回顾性病例对照研究。
Lancet. 2017 Sep 30;390(10102):1603-1610. doi: 10.1016/S0140-6736(17)31449-6. Epub 2017 Jul 10.
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Norovirus vaccines under development.正在开发的诺如病毒疫苗。
Vaccine. 2018 Aug 28;36(36):5435-5441. doi: 10.1016/j.vaccine.2017.06.043. Epub 2017 Jun 28.
4
High burden of antimicrobial resistance among gram negative bacteria causing healthcare associated infections in a critical care unit of Nepal.尼泊尔一家重症监护病房中引起医疗保健相关感染的革兰氏阴性菌的抗菌药物耐药性负担沉重。
Antimicrob Resist Infect Control. 2017 Jun 15;6:67. doi: 10.1186/s13756-017-0222-z. eCollection 2017.
5
Impact of the introduction of pneumococcal conjugate vaccination on pneumonia in The Gambia: population-based surveillance and case-control studies.肺炎球菌结合疫苗的引入对冈比亚肺炎的影响：基于人群的监测和病例对照研究。
Lancet Infect Dis. 2017 Sep;17(9):965-973. doi: 10.1016/S1473-3099(17)30321-3. Epub 2017 Jun 7.
6
Design of live attenuated bacterial vaccines based on D-glutamate auxotrophy.基于 D-谷氨酸营养缺陷型的减毒活菌疫苗设计。
Nat Commun. 2017 May 26;8:15480. doi: 10.1038/ncomms15480.
7
Hospital-acquired rotavirus and norovirus acute gastroenteritis in a pediatric unit, in 2014-2015.2014-2015 年，儿科病房发生医院获得性轮状病毒和诺如病毒急性肠胃炎。
J Med Virol. 2017 Oct;89(10):1768-1774. doi: 10.1002/jmv.24866. Epub 2017 Jul 10.
8
Vaccination with a live attenuated Acinetobacter baumannii deficient in thioredoxin provides protection against systemic Acinetobacter infection.接种缺乏硫氧还蛋白的减毒活鲍曼不动杆菌可提供针对全身性鲍曼不动杆菌感染的保护。
Vaccine. 2017 Jun 8;35(26):3387-3394. doi: 10.1016/j.vaccine.2017.05.017. Epub 2017 May 15.
9
Impact of respiratory viruses in hospital-acquired pneumonia in the intensive care unit: A single-center retrospective study.呼吸道病毒对重症监护病房医院获得性肺炎的影响：一项单中心回顾性研究。
J Clin Virol. 2017 Jun;91:52-57. doi: 10.1016/j.jcv.2017.04.001. Epub 2017 Apr 22.
10
Why does drug resistance readily evolve but vaccine resistance does not?为什么耐药性很容易产生，而疫苗抗性却不会呢？
Proc Biol Sci. 2017 Mar 29;284(1851). doi: 10.1098/rspb.2016.2562.

医疗保健相关感染：通过接种疫苗预防的可能性。

Healthcare-associated infections: potential for prevention through vaccination.

作者信息

McIntosh E David G

机构信息

Honorary Clinical Senior Lecturer, Imperial College, London SW7 2AZ, UK.

出版信息

Ther Adv Vaccines Immunother. 2018 Feb;6(1):19-27. doi: 10.1177/2515135518763183. Epub 2018 Mar 14.

DOI:10.1177/2515135518763183
PMID:29998218
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5933536/
Abstract

The challenge of healthcare-associated infections is compounded by the higher incidence of resistant organisms and the decreasing utility of antimicrobial agents. Historic and current vaccines have already contributed to reductions in healthcare-associated infections, and future vaccines have the potential to reduce these infections further. Through examples of bacterial and viral vaccines, this review will attempt to chart the way forward.

摘要

耐药菌发病率的上升以及抗菌药物效用的降低，使医疗保健相关感染的挑战更加复杂。历史上和当前的疫苗已经有助于减少医疗保健相关感染，未来的疫苗有可能进一步降低这些感染的发生率。通过细菌和病毒疫苗的实例，本综述将尝试规划前进的道路。