具有治疗功能的药物递送载体。
Drug delivery carriers with therapeutic functions.
机构信息
Department of Biomedical Engineering, Columbia University, New York 10027, New York, United States.
Graduate Program in Cellular, Molecular and Biomedical Studies, Vagelos College of Physicians and Surgeons, Columbia University, New York 10027, New York, United States.
出版信息
Adv Drug Deliv Rev. 2021 Sep;176:113884. doi: 10.1016/j.addr.2021.113884. Epub 2021 Jul 21.
Design of micro- or nanocarriers for drug delivery has primarily been focused on properties such as hydrophobicity, biodegradability, size, shape, surface charge, and toxicity, so that they can achieve optimal delivery with respect to drug loading, release kinetics, biodistribution, cellular uptake, and biocompatibility. Incorporation of stimulus-sensitive moieties into the carriers would lead to "smart" delivery systems. A further evolution would be to endow the carrier with a therapeutic function such that it no longer serves as a mere passive entity to release the drug at the target tissue but can be viewed as a therapeutic agent in itself. In this review, we will discuss recent and ongoing efforts over the past decade to design therapeutic drug carriers that confer a biological benefit, including ROS scavenging or generating, pro- or anti-inflammatory, and immuno-evasive properties, to enhance the overall therapeutic efficacy of the delivery systems.
药物输送用的微纳米载体的设计主要集中在疏水性、生物降解性、尺寸、形状、表面电荷和毒性等性质上，以便在药物负载、释放动力学、生物分布、细胞摄取和生物相容性方面达到最佳输送效果。将刺激响应性部分整合到载体中会导致“智能”输送系统。进一步的发展将是赋予载体治疗功能，使其不再仅仅是在靶组织释放药物的被动实体，而是可以被视为自身的治疗剂。在这篇综述中，我们将讨论过去十年中设计具有生物益处的治疗性药物载体的最新和正在进行的努力，包括清除或产生 ROS、促炎或抗炎以及免疫逃避特性，以提高输送系统的整体治疗效果。
Zotero 插件