Demir Arzu Meltem, Kuloğlu Zarife, Yaman Aytaç, Fitöz Suat, Nergizoğlu Gökhan, Kansu Aydan
Division of Pediatric Gastroenterology, Department of Pediatrics, Ankara University Faculty of Medicine, Ankara, Turkey.
Department of Radiology, Ankara University Faculty of Medicine, Ankara, Turkey.
Turk J Pediatr. 2016;58(2):172-179. doi: 10.24953/turkjped.2016.02.008.
The association between pediatric celiac disease (CD) and atherosclerosis is unknown. Our aim was to investigate whether pediatric CD patients have an increased risk of atherosclerosis. We evaluated the premature atherosclerosis by pulse wave velocity (PWV) and carotid intima-media thickness (cIMT). A total of 37 CD patients (20 girls, mean age 13±3.3 years) and 36 healthy age and sex matched controls were enrolled. Mean duration of CD was 47.1±32.3 months and 40.5% of patients had positive tissue transglutaminase antibody (tTg) IgA. Total cholesterol level was lower in CD (p=0.026) and cIMT was lower in tTg IgA antibody negative CD (p=0.030). cIMT was significantly correlated with tTg IgA antibody positivity (r=0.336; p=0.042). Adherence to strict gluten-free diet is associated with decreased cIMT, suggesting that gluten withdrawal seems to have a beneficial effect on premature atherosclerosis.
小儿乳糜泻（CD）与动脉粥样硬化之间的关联尚不清楚。我们的目的是调查小儿CD患者患动脉粥样硬化的风险是否增加。我们通过脉搏波速度（PWV）和颈动脉内膜中层厚度（cIMT）评估早期动脉粥样硬化。共纳入37例CD患者（20名女孩，平均年龄13±3.3岁）和36名年龄及性别匹配的健康对照者。CD的平均病程为47.1±32.3个月，40.5%的患者组织转谷氨酰胺酶抗体（tTg）IgA呈阳性。CD患者总胆固醇水平较低（p = 0.026），tTg IgA抗体阴性的CD患者cIMT较低（p = 0.030）。cIMT与tTg IgA抗体阳性显著相关（r = 0.336；p = 0.042）。坚持严格的无麸质饮食与cIMT降低有关，这表明戒除麸质似乎对早期动脉粥样硬化有有益影响。
