Sarwar Hooria, Koneru Hema Manvi, Sinha Mohit, Tarar Pakeeza, Maged Rafik, Bandi Venkata Varshitha, Malasevskaia Iana
Psychiatry, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA.
Internal Medicine, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA.
Cureus. 2024 Sep 10;16(9):e69086. doi: 10.7759/cureus.69086. eCollection 2024 Sep.
Celiac disease, a serious autoimmune disease, is triggered by the ingestion of gluten. It is associated with many gastrointestinal and extraintestinal symptoms. The cornerstone of treatment is a strict gluten-free diet (GFD). This paper collected studies that were screened between the 15th and 25th of June 2024 and were searched for from many databases and registers, including PubMed, Medline, ClinicalTrials.gov, Cochrane Library, Europe PMC, and EBSCO Open Dissertations. We have included the 12 most relevant studies that examined the effects of GFD adherence among pediatric patients with celiac disease. Evidence suggests that a GFD caused notable improvements in liver function, growth metrics, and quality of life indices. Extraintestinal symptoms such as cardiac dysfunctions and obstructive sleep apnea also showed compelling improvement. We conclude that there are substantial advantages of a GFD in children with celiac disease and call for the need for personal nutritional support to address nutritional deficiencies and long-term studies and comprehensive strategies to optimize treatment outcomes and improve the quality of life for affected children.
乳糜泻是一种严重的自身免疫性疾病，由摄入麸质引发。它与许多胃肠道和肠外症状相关。治疗的基石是严格的无麸质饮食（GFD）。本文收集了于2024年6月15日至25日筛选的研究，这些研究来自多个数据库和登记处，包括PubMed、Medline、ClinicalTrials.gov、Cochrane图书馆、欧洲PMC和EBSCO开放学位论文库。我们纳入了12项最相关的研究，这些研究考察了乳糜泻儿科患者坚持GFD的效果。有证据表明，GFD能显著改善肝功能、生长指标和生活质量指数。心脏功能障碍和阻塞性睡眠呼吸暂停等肠外症状也有明显改善。我们得出结论，GFD对乳糜泻儿童有诸多益处，并呼吁需要提供个人营养支持以解决营养缺乏问题，还需要开展长期研究并制定综合策略，以优化治疗效果并提高患病儿童的生活质量。
