Epstein J B, Loh R, Stevenson-Moore P, McBride B C, Spinelli J
Cancer Control Agency of British Columbia, Vancouver, Canada.
Oral Surg Oral Med Oral Pathol. 1989 Oct;68(4):401-5. doi: 10.1016/0030-4220(89)90136-9.
Patients who receive cancer radiotherapy, which compromises salivary gland function, may develop xerostomia. These patients are at increased risk to develop rampant dental caries. Streptococcus mutans and species of lactobacillus have been associated with dental caries. Quantitative counts of these organisms demonstrated high caries risk in 85% of patients studied. The use of chlorhexidine rinse to reduce the counts of S. mutans and lactobacillus was studied. A modest reduction in S. mutans was seen, but little effect was demonstrated on lactobacillus counts. Caries activity was shown to be related to lactobacillus count.
接受会损害唾液腺功能的癌症放疗的患者可能会出现口干症。这些患者患猖獗性龋齿的风险增加。变形链球菌和乳酸菌属与龋齿有关。对这些微生物的定量计数表明，在85%的研究患者中存在高龋齿风险。研究了使用洗必泰漱口水来减少变形链球菌和乳酸菌数量的情况。发现变形链球菌数量有适度减少，但对乳酸菌数量几乎没有影响。龋齿活动被证明与乳酸菌数量有关。
