Zickert I, Emilson C G, Krasse B
Arch Oral Biol. 1982;27(10):861-8. doi: 10.1016/0003-9969(82)90042-5.
The number of Strep. mutans in saliva samples was examined in 101 13-14-year-old children, 53 in a control and 48 in the test group. All in the test group with 2.5 X 10(5) Strep. mutans per ml saliva were treated with 1 per cent chlorhexidine gel, once a day, for 14 days when the number of Strep. mutans was greatly reduced. Saliva samples were then examined in the test group every 4th month and all children with Strep. mutans levels above 2.5 X 10(5) were treated. A few selected children had fissure sealants applied to the occlusal surfaces. After 3 years, the mean number of new carious lesions was 9.6 in the control group and 4.2 in the test group. In the children with 10(6) Strep. mutans at the start of the study, the corresponding figures were 20.8 compared with 3.9. Thus a reduction in caries activity can be achieved by controlled antimicrobial treatment.
对101名13 - 14岁儿童的唾液样本中的变形链球菌数量进行了检测，其中对照组53名，试验组48名。试验组中唾液每毫升含2.5×10⁵变形链球菌的所有儿童，每天用1%洗必泰凝胶治疗一次，持续14天，之后变形链球菌数量大幅减少。然后试验组每4个月检测一次唾液样本，所有变形链球菌水平高于2.5×10⁵的儿童都接受治疗。少数选定的儿童在咬合面进行了窝沟封闭。3年后，对照组新龋损的平均数量为9.6，试验组为4.2。在研究开始时变形链球菌数量为10⁶的儿童中，相应数字分别为20.8和3.9。因此，通过控制性抗菌治疗可以实现龋齿活动的降低。
