Rask P I, Emilson C G, Krasse B, Sundberg H
Department of Cariology, Faculty of Odontology, University of Göteborg, Sweden.
Scand J Dent Res. 1988 Dec;96(6):500-4. doi: 10.1111/j.1600-0722.1988.tb01589.x.
Salivary and microbial conditions were examined in 124 50-60-yr-old patients attending a dental clinic of the Public Dental Health Service. They were then randomly divided into a control and a test group. Patients with low salivary secretion rate and buffer capacity and high numbers of mutans streptococci and lactobacilli in the test group received special caries preventive measures during 1 yr. In the control group all patients were given prevention according to routine procedures. The incidence of dental caries between the groups was compared. The risk patients in the control group developed 1.67 new carious lesions as compared to 0.19 in the test group. The difference was statistically significant (P less than 0.05). Also the numbers of mutans streptococci and lactobacilli were significantly lower in the risk patients in the test group after 1 yr compared with baseline values. After the experimental year all patients were treated according to routine procedures. Five years after the start of the study a new examination showed increased caries activity in the risk patients in the test group and the gain which had been made during the experimental year was almost lost.
在公共牙科保健服务机构的牙科诊所就诊的124名50至60岁患者接受了唾液和微生物状况检查。然后他们被随机分为对照组和试验组。试验组中唾液分泌率和缓冲能力低、变形链球菌和乳酸杆菌数量多的患者在1年中接受了特殊的防龋措施。对照组的所有患者均按照常规程序进行预防。比较了两组之间的龋齿发病率。对照组中的高危患者出现了1.67个新的龋损，而试验组为0.19个。差异具有统计学意义（P<0.05）。此外，试验组中的高危患者在1年后变形链球菌和乳酸杆菌的数量与基线值相比也显著降低。实验年结束后，所有患者均按照常规程序进行治疗。研究开始五年后，一项新的检查显示试验组中的高危患者龋齿活动增加，实验年期间取得的进展几乎丧失。
